公开(公告)号：US20220125390A1

公开(公告)日：2022-04-28

申请号：US17568791

申请日：2022-01-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Siddharth Krishnan ,  Tyler R. Ray ,  Amit B. Ayer ,  Philipp Gutruf ,  Jonathan T. Reeder ,  Kun Hyuck Lee ,  Chun-Ju Su

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

公开(公告)号：US11259754B2

公开(公告)日：2022-03-01

申请号：US17043111

申请日：2019-03-29

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Siddharth Krishnan ,  Tyler R. Ray ,  Amit B. Ayer ,  Philipp Gutruf ,  Jonathan T. Reeder ,  Kun Hyuck Lee ,  Chun-Ju Su

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

公开(公告)号：US11786168B2

公开(公告)日：2023-10-17

申请号：US16616898

申请日：2018-06-01

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Johnathan T. Reeder ,  Amay J. Bandodkar ,  Sungbong Kim ,  Yurina Sekine ,  Jungil Choi ,  Tyler R. Ray ,  Aurelie Hourlier-Fargette ,  Philipp Gutruf ,  Kun Hyuck Lee ,  Milan Raj

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/01 ,  A61B5/103

CPC classification number: A61B5/4266 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/1032 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B2562/0242 ,  A61B2562/0276 ,  A61B2562/164

Abstract: The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

公开(公告)号：US20220125389A1

公开(公告)日：2022-04-28

申请号：US17568771

申请日：2022-01-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Siddharth Krishnan ,  Tyler R. Ray ,  Amit B. Ayer ,  Philipp Gutruf ,  Jonathan T. Reeder ,  Kun Hyuck Lee ,  Chun-Ju Su

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

公开(公告)号：US20240260910A1

公开(公告)日：2024-08-08

申请号：US18633768

申请日：2024-04-12

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Siddharth Krishnan ,  Tyler R. Ray ,  Amit B. Ayer ,  Philipp Gutruf ,  Jonathan T. Reeder ,  Kun Hyuck Lee ,  Chun-Ju Su

IPC: A61B5/00 ,  A61B5/01

CPC classification number: A61B5/7278 ,  A61B5/01 ,  A61B2562/0271 ,  A61B2562/164 ,  A61B2562/18

Abstract: Hydrocephalus and shunt-related expenditures cost the US system over $2 billion dollars in annual expenses, with 125,000 shunt surgeries per year and an untreated mortality rate estimated at 50-60%. Existing diagnostics are expensive, inaccurate, and often harmful or invasive, and can lead to unnecessary admissions, further testing, or needless surgery. Collaborative efforts between Northwestern materials engineers headed by Dr. John Rogers alongside the leadership of neurological surgeons at Northwestern Memorial Hospital and Lurie Children's Hospital have produced and validated a noninvasive, thermal biosensor capable of diagnosing ventricular shunt malfunction.

公开(公告)号：US11439356B2

公开(公告)日：2022-09-13

申请号：US17568771

申请日：2022-01-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Siddharth Krishnan ,  Tyler R. Ray ,  Amit B. Ayer ,  Philipp Gutruf ,  Jonathan T. Reeder ,  Kun Hyuck Lee ,  Chun-Ju Su

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

公开(公告)号：US12144579B2

公开(公告)日：2024-11-19

申请号：US17043161

申请日：2019-03-29

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Shuai Xu ,  Yajing Li ,  Philipp Gutruf ,  Surabhi R. Madhvapathy ,  Siddharth Krishnan

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are wireless electronic devices for thermally interfacing with a biological tissue. The device may have a flexible substrate; a thermal actuator supported by said flexible substrate configured to provide a thermal input to said biological tissue; a temperature sensor supported by said flexible substrate configured to measure a temperature to determine thermal conductivity of said biological tissue; and a wireless electronic system in electronic communication with said thermal actuator and said temperature sensor, wherein said wireless electronic system is configured to provide two-way communication with an external controller. Also provided are related methods of using the electronic devices, including for cosmetic, beauty, or medical applications.