公开(公告)号：US20220370490A1

公开(公告)日：2022-11-24

申请号：US17749977

申请日：2022-05-20

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Ziyin Huang ,  Lisa Cole ,  Cassandra Elizabeth Callmann ,  Shuya Wang

IPC: A61K31/713 ,  A61P37/04 ,  A61K9/127

Abstract: The present disclosure is generally directed to spherical nucleic acids (SNAs) comprising multiple TLR agonists that enable the simultaneous activation of multiple TLR pathways for maximally synergistic immune activation. In some aspects, the present disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; (b) one or more toll-like receptor 3 (TLR3) agonists encapsulated in the nanoparticle core; and (c) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more toll-like receptor 9 (TLR9) agonist oligonucleotides. Methods of using the SNAs are also provided herein.