公开(公告)号：US20220288181A1

公开(公告)日：2022-09-15

申请号：US17684269

申请日：2022-03-01

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Michelle Hope Teplensky ,  Max Everett Distler ,  Caroline Danielle Kusmierz ,  Cassandra Elizabeth Callmann

IPC: A61K39/00 ,  A61P35/00 ,  A61K39/39 ,  C12N15/113

Abstract: Spherical Nucleic Acids (SNAs) are chemically well-defined nanoscale architectures comprised of nucleic acids densely arranged around a spherical nanoparticle core in a highly oriented fashion. SNAs are highly modular structures produced by chemical synthesis and programmed assembly, allowing for their rapid modification to incorporate novel viral antigens. The present disclosure provides a SNA comprising (a) a nanoparticle core; (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more immunostimulatory oligonucleotides; and (c) a viral antigen encapsulated in the nanoparticle core.

公开(公告)号：US20230147733A1

公开(公告)日：2023-05-11

申请号：US17917871

申请日：2021-04-09

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Cassandra Elizabeth Callmann

IPC: A61K39/00 ,  C12N5/09 ,  C12N15/117 ,  A61K47/69 ,  A61K47/64 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K39/0011 ,  C12N5/0693 ,  C12N15/117 ,  A61K47/6915 ,  A61K47/64 ,  A61K47/545 ,  A61P35/00 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/3515

Abstract: The disclosure is generally related to nanoparticles have an oxidized tumor cell lysate encapsulated therein and oligonucleotides on the surface thereof. Methods of making and using the nanoparticles are also provided herein.

公开(公告)号：US20220370490A1

公开(公告)日：2022-11-24

申请号：US17749977

申请日：2022-05-20

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Ziyin Huang ,  Lisa Cole ,  Cassandra Elizabeth Callmann ,  Shuya Wang

IPC: A61K31/713 ,  A61P37/04 ,  A61K9/127

Abstract: The present disclosure is generally directed to spherical nucleic acids (SNAs) comprising multiple TLR agonists that enable the simultaneous activation of multiple TLR pathways for maximally synergistic immune activation. In some aspects, the present disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; (b) one or more toll-like receptor 3 (TLR3) agonists encapsulated in the nanoparticle core; and (c) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more toll-like receptor 9 (TLR9) agonist oligonucleotides. Methods of using the SNAs are also provided herein.