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1.
公开(公告)号:US20220142516A1
公开(公告)日:2022-05-12
申请号:US17451363
申请日:2021-10-19
Applicant: NUEON INC.
Inventor: Robert G. MESSERSCHMIDT , Hershel MACAULAY , Dara ROUHOLIMAN
Abstract: A blood sample collector can be used to collect a blood sample from a subject. The blood sample collector can be placed in a receptacle of a spectrometer to measure spectral data from the blood sample while the blood sample separates. The container may comprise a window to allow light such as infrared light to pass through the container, with the blood sample at least partially separating within the container between spectral measurements, which can provide improved accuracy of the measurements and additional information regarding the sample. Measurements of the level of a biomarker surrogate in a person's blood may be used to assist the person to make beneficial changes to their diet, exercise regimen, or other aspects of their lifestyle.
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公开(公告)号:US20210364421A1
公开(公告)日:2021-11-25
申请号:US17303995
申请日:2021-06-11
Applicant: NUEON INC.
Inventor: Robert G. MESSERSCHMIDT , Howland D. T. JONES
Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
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公开(公告)号:US20170350814A1
公开(公告)日:2017-12-07
申请号:US15620269
申请日:2017-06-12
Applicant: NUEON INC.
Inventor: Robert G. MESSERSCHMIDT , Howland D. T. JONES
CPC classification number: G01N21/27 , A61B5/0075 , A61B5/02 , A61B5/4833 , G01N21/59 , G01N33/492 , G01N2201/06113 , G01N2201/068
Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.
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公开(公告)号:US20210223168A1
公开(公告)日:2021-07-22
申请号:US17250006
申请日:2019-04-30
Applicant: NUEON INC.
Inventor: Robert G. MESSERSCHMIDT
Abstract: A blood sample collector can be used to collect a blood sample from a subject. The blood sample collector can be placed in a receptacle of a spectrometer to measure spectral data from the blood sample while the blood sample separates. The container may comprise a window to allow light such as infrared light to pass through the container, with the blood sample at least partially separating within the container between spectral measurements, which can provide improved accuracy of the measurements and additional information regarding the sample. The container may comprise an elongate axis and the container configured for placement in the spectrometer receptacle with the elongate axis extending toward a vertical direction in order to improve gravimetric separation of the blood sample. The spectrometer can be configured to measure the blood sample at a plurality of heights along the sample as the sample separates.
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5.
公开(公告)号:US20220225908A1
公开(公告)日:2022-07-21
申请号:US17581595
申请日:2022-01-21
Applicant: NUEON INC.
Inventor: Robert G. MESSERSCHMIDT , Hershel MACAULAY , Dara ROUHOLIMAN
IPC: A61B5/145 , A61B5/1455 , A61B5/00
Abstract: Systems, apparatuses and methods for the non-invasive measurement of a surrogate for a biomarker in a person's blood. In the example where the surrogate is a level of fat in the blood of the person and the biomarker is the level of triglycerides in the person's blood, the correlation between measurements of the surrogate and the level of triglycerides may be used to generate a recommendation to the person regarding a change in their intake of food, their exercise regimen, or another aspect of their lifestyle.
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公开(公告)号:US20210381958A1
公开(公告)日:2021-12-09
申请号:US17304928
申请日:2021-06-28
Applicant: NUEON INC.
Inventor: Robert G. MESSERSCHMIDT
IPC: G01N21/27 , G01N21/35 , A61B5/1455 , A61B5/00 , A61B5/026 , A61B5/145 , G01N21/33 , G01N21/65 , G01N33/49
Abstract: A measurement apparatus comprises optical components arranged to provide parallel measurements of a biological sample. The parallel sample measurements provide improved accuracy with lower detection limit thresholds. The parallel measurements may comprise one or more of Raman spectroscopy measurements or infrared spectroscopy measurements. The parallel measurements can be combined with a light source. In many embodiments, the light source comprises one or more wavelengths corresponding to resonance frequencies of one or more molecules of the sample, such as wavelengths of ultraviolet light. The wavelengths of light corresponding to resonance frequencies can provide an increased signal to noise ratio. The parallel array optical configuration can be combined with wavelengths of light corresponding to resonance frequencies in order to provide increased measurement accuracy and detection of metabolites.
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