公开(公告)号：US20220135748A1

公开(公告)日：2022-05-05

申请号：US17219915

申请日：2021-04-01

Applicant: National Taiwan University of Science and Technology

Inventor： Hsieh-Chih TSAI ,  Shuian-Yin LIN ,  Hsiao-Ying CHOU

IPC: C08J3/075 ,  C08J3/24 ,  A61L26/00

Abstract: The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

公开(公告)号：US20230310320A1

公开(公告)日：2023-10-05

申请号：US17662847

申请日：2022-05-11

Applicant: National Taiwan University of Science and Technology

Inventor： Hsieh-Chih TSAI ,  Shuian-Yin LIN ,  Ming-Chien YANG ,  Chun-Chiang HUANG ,  Yu-Hsuan LIN

IPC: A61K9/16

CPC classification number: A61K9/1658 ,  A61K9/1617 ,  A61K9/1635

Abstract: The present disclosure provides a soluble microcarrier, including soluble polymer including a plurality of soluble monomers binding to each other with a reducing crosslinking agent. The soluble microcarrier of present disclosure facilitates the attachment of cells, and reducing agents can facilitate the detachment of cells. When the soluble microcarrier is in contact with a reducing agent, the soluble microcarrier degrades.