公开(公告)号：US20190110680A1

公开(公告)日：2019-04-18

申请号：US16219162

申请日：2018-12-13

Applicant: Olympus Corporation

Inventor： Hiroya Fukuyama

IPC: A61B3/10 ,  G02B9/60 ,  G02B26/10 ,  G02B7/04

Abstract: The disclosed technology is directed to placing two galvanometer mirrors in a pupil conjugate relationship and at the same time preventing astigmatism from occurring while preventing images from being degraded by flaws and foreign matter on a lens. A scanning optical system includes two one-dimensional scanning means disposed closely to each other at a spaced interval therebetween in an optical axis direction for scanning a light beam from a light source in two scanning directions. An objective lens for focusing the light beam scanned by the scanning means onto a target. A plurality of optical elements is disposed in positions spaced from an intermediate image plane in the optical axis direction and having different optical powers in the two scanning directions. The positions and the optical powers of the respective optical elements are set to compensate for the spaced interval between the two scanning means in the optical axis direction.

公开(公告)号：US09513223B2

公开(公告)日：2016-12-06

申请号：US14829983

申请日：2015-08-19

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya Fukuyama

IPC: G01J1/58 ,  G01T1/10 ,  G01N21/64 ,  G02B21/06 ,  G02B21/36

CPC classification number: G01N21/6456 ,  G01N2201/10 ,  G01N2201/121 ,  G02B21/06 ,  G02B21/365

Abstract: A high-resolution fluorescence image in which an afterimage is suppressed is obtained, even when a fluorescence detection interval is shortened. Provided is a scanning observation apparatus including a scanning unit that spatially scans pulsed excitation light emitted from a light source at prescribed time intervals on a specimen; a fluorescence detecting unit that detects fluorescence generated by exciting a fluorescent substance inside the specimen with the excitation light scanned by the scanning unit, in synchronization with the emission of the excitation light; and a fluorescence correcting unit that subtracts, from a fluorescence intensity detected by the fluorescence detecting unit, an afterimage fluorescence component calculated on the basis of time-sequential fluorescence detected by the fluorescence detecting unit prior thereto, at each scanning position, to correct the fluorescence intensity at the scanning position.

Abstract translation: 即使在荧光检测间隔缩短的情况下也能够得到抑制残像的高分辨率的荧光图像。 本发明提供一种扫描观察装置，其具备：扫描单元，其以规定的时间间隔在样本上空间扫描从光源发出的脉冲激发光; 荧光检测单元，其与通过所述激发光的发射同步地检测利用所述扫描单元扫描的激发光来激发所述样本内的荧光物质而产生的荧光; 以及荧光校正单元，从荧光检测单元检测出的荧光强度，在每个扫描位置根据荧光检测单元检测到的时间序列荧光计算的余像荧光成分，从而校正荧光 在扫描位置的强度。

公开(公告)号：US11096572B2

公开(公告)日：2021-08-24

申请号：US16219162

申请日：2018-12-13

Applicant: Olympus Corporation

Inventor： Hiroya Fukuyama

IPC: A61B3/10 ,  G02B13/08 ,  G02B26/10 ,  G02B7/04 ,  G02B9/60

Abstract: The disclosed technology is directed to placing two galvanometer mirrors in a pupil conjugate relationship and at the same time preventing astigmatism from occurring while preventing images from being degraded by flaws and foreign matter on a lens. A scanning optical system includes two one-dimensional scanning means disposed closely to each other at a spaced interval therebetween in an optical axis direction for scanning a light beam from a light source in two scanning directions. An objective lens for focusing the light beam scanned by the scanning means onto a target. A plurality of optical elements is disposed in positions spaced from an intermediate image plane in the optical axis direction and having different optical powers in the two scanning directions. The positions and the optical powers of the respective optical elements are set to compensate for the spaced interval between the two scanning means in the optical axis direction.

公开(公告)号：US10168283B2

公开(公告)日：2019-01-01

申请号：US15410828

申请日：2017-01-20

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya Fukuyama

IPC: G02B21/06 ,  G02B26/10 ,  G01N21/64 ,  G02B21/00 ,  G02B21/16

Abstract: Acquiring a sharp final image by preventing, even when an intermediate image is formed at a position overlapping an optical element, a flaw or the like on the optical element from being superimposed on the intermediate image. An observation apparatus including: an image-forming optical system having image-forming lenses that form a final image and an intermediate image, a first phase modulator that applies a spatial disturbance to the wavefront of light, and a second phase modulator that cancels out the spatial disturbance; a light source; an XY-scanning part including a first and a second scanner; and a photodetector. The two phase modulators are disposed at positions optically conjugate with the first scanner and have one-dimensional phase-distribution characteristics changing in the scanning direction of the illumination light.

公开(公告)号：US10330905B2

公开(公告)日：2019-06-25

申请号：US15477644

申请日：2017-04-03

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya Fukuyama

IPC: G02B21/02 ,  G02B21/00 ,  G02B21/06 ,  G02B27/00 ,  G02B13/00 ,  G02B21/24 ,  G02B23/12 ,  G02B23/24 ,  H04N5/225

Abstract: Provided is a microscope apparatus including: a light source; an illumination optical system that radiates illumination light from the light source onto an observation object; an imaging optical system that focuses light from the observation object; and an image acquisition device that acquires an image of the light focused by the imaging optical system. The imaging optical system is provided with: imaging lenses that form a final image and at least one intermediate image; a first phase modulation element that is disposed closer to an object than any of the at least one intermediate image and that gives a spatial disturbance to the wavefront of light from the object; a second phase modulation element that is disposed at a position for allowing the at least one intermediate image to be sandwiched with the first phase modulation element and that cancels out the spatial disturbance given to the wavefront.

公开(公告)号：US10422747B2

公开(公告)日：2019-09-24

申请号：US15408687

申请日：2017-01-18

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya Fukuyama

IPC: G01C3/08 ,  G01N21/64 ,  G02B3/06 ,  G02B23/26 ,  G02B21/00

Abstract: The imaging optical system is for acquiring a clear final image, even if an intermediate image is formed at a position that overlaps with an optical device, by preventing scratches or the like of the optical device from becoming superimposed on the intermediate image, and has imaging lenses that form a final image and at least one intermediate image, a first phase-modulating element that imparts a spatial disturbance to a wavefront of light from an object, and a second phase-modulating element disposed at a position so that at least one intermediate image is interposed between the element and the element and that cancels the spatial disturbance, wherein the element has cylindrical lenses arranged with a space therebetween, and arranged so that a principal point of the whole system is positioned in a vicinity of a pupil position of the imaging lenses.

公开(公告)号：US10108008B2

公开(公告)日：2018-10-23

申请号：US14873592

申请日：2015-10-02

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya Fukuyama

IPC: G02F1/01 ,  G02B27/00 ,  G02B13/22 ,  G02B21/00 ,  G02B21/04 ,  G02B21/36 ,  G02B3/08 ,  G02B5/18 ,  G02B13/08 ,  G02B26/06

Abstract: An image-forming optical system includes a plurality of image-forming lenses that form a final image and at least one intermediate image; a first phase modulator that is disposed closer to an object side than any one of the intermediate images formed by the image-forming lenses and that applies a spatial disturbance to a wavefront of light coming from the object; and a second phase modulator that is disposed at a position that sandwiches at least one of the intermediate images with the first phase modulator and that cancels out the spatial disturbance applied to the wavefront of the light coming from the object by the first phase modulator.

公开(公告)号：US20150238089A1

公开(公告)日：2015-08-27

申请号：US14708654

申请日：2015-05-11

Applicant: OLYMPUS CORPORATION

Inventor： Ken Fujinuma ,  Hiroya Fukuyama

IPC: A61B5/00 ,  A61B1/06 ,  A61B1/04 ,  A61B5/02 ,  A61B1/07 ,  A61B1/00

CPC classification number: A61B5/0086 ,  A61B1/00009 ,  A61B1/00045 ,  A61B1/00071 ,  A61B1/0008 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/04 ,  A61B1/042 ,  A61B1/0661 ,  A61B1/07 ,  A61B1/3137 ,  A61B5/0062 ,  A61B5/0064 ,  A61B5/0073 ,  A61B5/02007 ,  A61B5/1455 ,  A61B5/4887 ,  A61B5/489 ,  A61B5/7225 ,  A61B5/7278 ,  A61B2562/0233 ,  G01N21/4795

Abstract: There is provided an inside observation apparatus of an endoscope and the like which can perform an inside observation for irradiating an illumination light to a minute area of a surface of an object (for example, a living tissue) having a light scattering property and detecting a back-scattered light of the illumination light, can increase a detected light amount by a simply and low cost configuration by making an area of a detection region larger than an illumination region, and can reduce a time necessary to detect an body (for example, a blood vessel) to be observed and detect a region deeper than a conventional region.

Abstract translation: 提供了一种内窥镜等的内部观察装置，其能够进行向具有光散射性的物体（例如，活体组织）的表面的微小的面积照射照明光的内部观察，并且检测 通过使检测区域的面积大于照明区域，能够通过简单且低成本的构造来增加检测光量，并且可以减少检测身体所需的时间（例如， 血管），并且检测比常规区域更深的区域。