公开(公告)号：US20230221591A1

公开(公告)日：2023-07-13

申请号：US18096619

申请日：2023-01-13

Applicant: Purdue Research Foundation

Inventor： Chi Zhang ,  Mark Carlsen ,  Matthew Clark

IPC: G02F1/11 ,  G02F1/33

CPC classification number: G02F1/113 ,  G02F1/33

Abstract: The invention generally relates to systems and methods for controlling molecules. In certain aspects, the invention provides a system for controlling molecules, the system comprising: a first light source; a second light source; an acousto-optic modulator (AOM) coupled to the second light source; and control circuitry. In certain embodiments, the control circuitry may be configured to: receive a signal from the first light source that is interrogating a location in a sample that may contain a target molecule; compare the signal received from the first light source to a preset signal; and in the event that the signal received from the first light source meets or exceeds the preset signal, then the target molecule is present at the location in the sample and the control circuitry causes the AOM to activate the second light source to transmit light onto the location in the sample that contains the target molecule.

公开(公告)号：US11994473B2

公开(公告)日：2024-05-28

申请号：US17935563

申请日：2022-09-26

Applicant: Purdue Research Foundation

Inventor： Chi Zhang ,  Matthew Graham Clark

IPC: G01J3/44 ,  G01N21/21 ,  G01N21/65 ,  G01N33/483 ,  G02B21/00

CPC classification number: G01N21/65 ,  G01N21/21 ,  G01N33/4833 ,  G02B21/0032 ,  G02B21/0048 ,  G01N2021/653 ,  G01N2201/06113

Abstract: Embodiments of the present disclosure are disclosed for enhancing resolution for nonlinear optical microscopy. Embodiments include pulse picking using a modulator, such as an acousto-optic modulator, that is optionally controlled by a function generator or a frequency divider. Some embodiments spatially overlap two laser beams prior to the modulator, and still additional embodiments include separating the 1st diffraction order of the modulated laser output of the acousto-optic modulator and directing the 1st diffraction order to a microscope. Some embodiments chirp a spatially overlapped laser beam with one pulse rate to a spatially overlapped laser beam with a higher pulse rate, while still additional embodiments utilize a coherent Raman scattering microscope.