公开(公告)号：US11994473B2

公开(公告)日：2024-05-28

申请号：US17935563

申请日：2022-09-26

Applicant: Purdue Research Foundation

Inventor： Chi Zhang ,  Matthew Graham Clark

IPC: G01J3/44 ,  G01N21/21 ,  G01N21/65 ,  G01N33/483 ,  G02B21/00

CPC classification number: G01N21/65 ,  G01N21/21 ,  G01N33/4833 ,  G02B21/0032 ,  G02B21/0048 ,  G01N2021/653 ,  G01N2201/06113

Abstract: Embodiments of the present disclosure are disclosed for enhancing resolution for nonlinear optical microscopy. Embodiments include pulse picking using a modulator, such as an acousto-optic modulator, that is optionally controlled by a function generator or a frequency divider. Some embodiments spatially overlap two laser beams prior to the modulator, and still additional embodiments include separating the 1st diffraction order of the modulated laser output of the acousto-optic modulator and directing the 1st diffraction order to a microscope. Some embodiments chirp a spatially overlapped laser beam with one pulse rate to a spatially overlapped laser beam with a higher pulse rate, while still additional embodiments utilize a coherent Raman scattering microscope.