公开(公告)号：US20230248835A1

公开(公告)日：2023-08-10

申请号：US18004656

申请日：2021-07-07

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  John Victor NAPOLEON ,  Fenghua ZHANG

IPC: A61K47/55 ,  C07D471/04 ,  A61P35/00

CPC classification number: A61K47/551 ,  C07D471/04 ,  A61P35/00

Abstract: Compounds, including Toll-like receptor (TLR) agonists, e.g., TLR7 and TLR7/8 agonists and their folic acid or pteroyl amino acid conjugates, and use thereof to treat a cancer or a fibrotic disease or disorder; and methods of making conjugates comprising targeting ligands of folic acid receptor and TLR7 and TLR7/8 agonists.