公开(公告)号：US20240058458A1

公开(公告)日：2024-02-22

申请号：US17905748

申请日：2021-03-05

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  John Victor NAPOLEON ,  Qian LUO

IPC: A61K47/54 ,  A61K39/00 ,  A61K47/55 ,  A61K47/60

CPC classification number: A61K47/555 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/4646 ,  A61K47/551 ,  A61K47/558 ,  A61K47/60 ,  A61K2239/39

Abstract: Compounds, compositions and methods for reducing off-target toxicity of T cells expressing a chimeric antigen receptor (CAR-T cells) and/or providing enhanced control of CAR-T cell activation, and methods of treating a subject and/or modifying CAR-T cell activity in a subject with cancer.

公开(公告)号：US20240390505A1

公开(公告)日：2024-11-28

申请号：US18687785

申请日：2022-08-30

Applicant: Purdue Research Foundation

Inventor： Philip Stewart LOW ,  John Victor NAPOLEON

IPC: A61K47/55 ,  A61K39/00 ,  A61K47/60

Abstract: Chimeric antigen receptor (CAR) T-cell-rejuvenating conjugates and compositions and methods of use to rejuvenate exhausted CAR T-cells.

公开(公告)号：US20230248835A1

公开(公告)日：2023-08-10

申请号：US18004656

申请日：2021-07-07

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  John Victor NAPOLEON ,  Fenghua ZHANG

IPC: A61K47/55 ,  C07D471/04 ,  A61P35/00

CPC classification number: A61K47/551 ,  C07D471/04 ,  A61P35/00

Abstract: Compounds, including Toll-like receptor (TLR) agonists, e.g., TLR7 and TLR7/8 agonists and their folic acid or pteroyl amino acid conjugates, and use thereof to treat a cancer or a fibrotic disease or disorder; and methods of making conjugates comprising targeting ligands of folic acid receptor and TLR7 and TLR7/8 agonists.