公开(公告)号：US11739291B2

公开(公告)日：2023-08-29

申请号：US16607665

申请日：2018-04-25

Applicant: Purdue Research Foundation

Inventor： Sherry L. Voytik-Harbin ,  Stacey L. Halum ,  Sarah Brookes ,  Hongji Zhang

IPC: C07K14/78 ,  C12N5/00 ,  C12N5/077 ,  C12N5/074

CPC classification number: C12N5/0068 ,  C07K14/78 ,  C12N5/0062 ,  C12N5/0652 ,  C12N5/0696 ,  C12N2500/34 ,  C12N2533/54

Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.

公开(公告)号：US20230365923A1

公开(公告)日：2023-11-16

申请号：US18351488

申请日：2023-07-12

Applicant: Purdue Research Foundation

Inventor： Sherry L. Voytik-Harbin ,  Stacey L. Halum ,  Sarah Brookes ,  Hongji Zhang

IPC: C12N5/00 ,  C07K14/78 ,  C12N5/077 ,  C12N5/074

CPC classification number: C12N5/0068 ,  C07K14/78 ,  C12N5/0062 ,  C12N5/0652 ,  C12N5/0696 ,  C12N2500/34 ,  C12N2533/54

Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.