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公开(公告)号：US11919941B2
公开(公告)日：2024-03-05
申请号：US15568262
申请日：2016-04-21
Applicant: Purdue Research Foundation
Inventor： Jenna Leigh Rickus , Sherry L. Voytik-Harbin , Jennifer L. K. Rich
CPC classification number: C07K14/78 , C12N5/0012 , C12N5/0697 , C12N11/04 , C12N11/14
Abstract: Soluble, self-assembling collagens derived from tissues are extensively characterized such that one can predict and customize the final collagen-fibril matrix with respect to fibril microstructure (i.e., fibril density, interfibril branching), viscoelasticity and proteolytic degradability. As shown herein these matrices template and direct the deposition of mesoporous silica at the level of individual collagen fibrils. The fibril density, silicic acid concentration, and time of exposure to silicifying solution were varied and the resulting hybrid materials were analyzed by scanning electron microscopy, energy-dispersive x-ray spectroscopy, and rheology. Microstructural properties of the collagen-fibril template are preserved in the silica surface of hybrid materials. Results for three different collagen fibril densities, corresponding to shear storage moduli of 200 Pa, 1000 Pa, and 1600 Pa, indicate that increased fibril density increases the absolute amount of templated silica when all other silica synthesis conditions are kept constant. The mechanical properties of the hybrid material are dominated by the presence of the silica coating rather than the starting collagen matrix stiffness.
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公开(公告)号：US20180185553A1
公开(公告)日：2018-07-05
申请号：US15851732
申请日：2017-12-21
Applicant: Purdue Research Foundation
Inventor： Sherry L. Voytik-Harbin , Tyler Anthony Novak , Kevin Blum , Corey Philip Neu
CPC classification number: A61L31/044 , A61L27/24 , A61L27/50 , A61L27/56
Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
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公开(公告)号：US11739291B2
公开(公告)日：2023-08-29
申请号：US16607665
申请日：2018-04-25
Applicant: Purdue Research Foundation
Inventor： Sherry L. Voytik-Harbin , Stacey L. Halum , Sarah Brookes , Hongji Zhang
CPC classification number: C12N5/0068 , C07K14/78 , C12N5/0062 , C12N5/0652 , C12N5/0696 , C12N2500/34 , C12N2533/54
Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.
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公开(公告)号：US20200206275A1
公开(公告)日：2020-07-02
申请号：US16633549
申请日：2018-07-24
Inventor： Sherry L. Voytik-Harbin , Clarissa Hernandez Stephens
Abstract: Compositions comprising collagen and insulin-producing cells are provided. Processes for making such a collagen and insulin-producing cell compositions are also provided. Methods for controlling, or lowering blood glucose levels and treating metabolic disorders in mammals, including type 1 diabetes, with such compositions are further provided. Methods to prolong insulin-producing cell viability and function in vitro or during transport are also provided.
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公开(公告)号：US20230365923A1
公开(公告)日：2023-11-16
申请号：US18351488
申请日：2023-07-12
Applicant: Purdue Research Foundation
Inventor： Sherry L. Voytik-Harbin , Stacey L. Halum , Sarah Brookes , Hongji Zhang
CPC classification number: C12N5/0068 , C07K14/78 , C12N5/0062 , C12N5/0652 , C12N5/0696 , C12N2500/34 , C12N2533/54
Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.
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Patent Agency Ranking
公开(公告)号：US09878071B2
公开(公告)日：2018-01-30
申请号：US14515680
申请日：2014-10-16
Applicant: Purdue Research Foundation
Inventor： Tyler Anthony Novak , Kevin Blum , Corey Philip Neu , Sherry L. Voytik-Harbin
CPC classification number: A61L31/044 , A61L27/24 , A61L27/50 , A61L27/56
Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
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公开(公告)号：US12138368B2
公开(公告)日：2024-11-12
申请号：US17958959
申请日：2022-10-03
Applicant: Purdue Research Foundation
Inventor： Sherry L. Voytik-Harbin , Tylor Anthony Novak , Kevin Blum , Corey Philip Neu
Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
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公开(公告)号：US20230277734A1
公开(公告)日：2023-09-07
申请号：US17958959
申请日：2022-10-03
Applicant: Purdue Research Foundation
Inventor： Sherry L. Voytik-Harbin , Tylor Anthony Novak , Kevin Blum , Corey Philip Neu
CPC classification number: A61L31/044 , A61L27/24 , A61L27/50 , A61L27/56
Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
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公开(公告)号：US11478574B2
公开(公告)日：2022-10-25
申请号：US15851732
申请日：2017-12-21
Applicant: Purdue Research Foundation
Inventor： Sherry L. Voytik-Harbin , Tyler Anthony Novak , Kevin Blum , Corey Philip Neu
Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
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公开(公告)号：US20160186131A1
公开(公告)日：2016-06-30
申请号：US14978732
申请日：2015-12-22
Applicant: Purdue Research Foundation
Inventor： Sherry L. Voytik-Harbin
CPC classification number: C12N5/0062 , A61L27/24 , A61L27/34 , A61L27/3834 , A61L27/44 , A61L2430/00 , C12N5/0068 , C12N5/0663 , C12N5/0667 , C12N2533/54 , C08L89/06
Abstract: Cell culture scaffolds presenting a more biologically relevant microenvironment are disclosed. More particularly, these cell culture scaffolds comprise three-dimensional matrices/biomaterials that are created from solubilized collagen compositions using controlled conditions to have the desired microstructure and mechanical properties. The engineered purified collagen based matrix compositions of the present invention can be used alone or in combination with cells as a tissue graft construct to enhance the repair of damaged or diseased tissues.
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