公开(公告)号：US20230365923A1

公开(公告)日：2023-11-16

申请号：US18351488

申请日：2023-07-12

Applicant: Purdue Research Foundation

Inventor： Sherry L. Voytik-Harbin ,  Stacey L. Halum ,  Sarah Brookes ,  Hongji Zhang

IPC: C12N5/00 ,  C07K14/78 ,  C12N5/077 ,  C12N5/074

CPC classification number: C12N5/0068 ,  C07K14/78 ,  C12N5/0062 ,  C12N5/0652 ,  C12N5/0696 ,  C12N2500/34 ,  C12N2533/54

Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.

公开(公告)号：US11739291B2

公开(公告)日：2023-08-29

申请号：US16607665

申请日：2018-04-25

Applicant: Purdue Research Foundation

Inventor： Sherry L. Voytik-Harbin ,  Stacey L. Halum ,  Sarah Brookes ,  Hongji Zhang

IPC: C07K14/78 ,  C12N5/00 ,  C12N5/077 ,  C12N5/074

CPC classification number: C12N5/0068 ,  C07K14/78 ,  C12N5/0062 ,  C12N5/0652 ,  C12N5/0696 ,  C12N2500/34 ,  C12N2533/54

Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.

公开(公告)号：US11235005B2

公开(公告)日：2022-02-01

申请号：US15964784

申请日：2018-04-27

Applicant: Purdue Research Foundation

Inventor： Stacey L. Halum

IPC: A61K35/34 ,  A61P21/00 ,  A61P25/00 ,  A61P43/00 ,  A61K35/30 ,  C12N5/077 ,  A61K38/18 ,  A61K31/221

Abstract: This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle.

公开(公告)号：US20180311281A1

公开(公告)日：2018-11-01

申请号：US15964784

申请日：2018-04-27

Applicant: Purdue Research Foundation

Inventor： Stacey L. Halum

IPC: A61K35/34 ,  A61P21/00 ,  A61P25/00 ,  A61P43/00 ,  A61K35/30 ,  C12N5/077

Abstract: This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle.