Methods, algorithms and systems for sub-nanosecond digital signal processing of photomultiplier tube response to enable multi-photon counting in Raman spectroscopy

    公开(公告)号:US12123777B2

    公开(公告)日:2024-10-22

    申请号:US17730374

    申请日:2022-04-27

    CPC classification number: G01J3/4412 G01J3/44 G01N21/65 G01J2001/442

    Abstract: A method of determining the contributions of multiple incident photons to an output of a sensor, including providing a photonic sensor having a sensor input and capable of generating an electrical signal proportional to a number of photons interacting with the photonic sensor input as a function of time, calibrating the photonic sensor such that a response of the photonic sensor to a single photon detected is in a waveform having an amplitude and a time, wherein the product of the amplitude and the time is statistically bounded, determining a probabilistic boundary between one or more of electrical, optical, and thermal sources of noise of the sensor, acquiring a response wave form from the photonic sensor through analog-to-digital conversion with a resolution in amplitude and time corresponding to accuracy required in quantifying the response wave form, storing each acquired response wave form, individually, in a format selected from the group consisting of real-time and buffered packets in digital form, and determining a total count of likely photon arrivals for a specific time resolved acquisition.

    METHODS, ALGORITHMS AND SYSTEMS FOR SUB-NANOSECOND DIGITAL SIGNAL PROCESSING OF PHOTOMULTIPLIER TUBE RESPONSE TO ENABLE MULTI-PHOTON COUNTING IN RAMAN SPECTROSCOPY

    公开(公告)号:US20220341784A1

    公开(公告)日:2022-10-27

    申请号:US17730374

    申请日:2022-04-27

    Abstract: A method of determining the contributions of multiple incident photons to an output of a sensor, including providing a photonic sensor having a sensor input and capable of generating an electrical signal proportional to a number of photons interacting with the photonic sensor input as a function of time, calibrating the photonic sensor such that a response of the photonic sensor to a single photon detected is in a waveform having an amplitude and a time, wherein the product of the amplitude and the time is statistically bounded, determining a probabilistic boundary between one or more of electrical, optical, and thermal sources of noise of the sensor, acquiring a response wave form from the photonic sensor through analog-to-digital conversion with a resolution in amplitude and time corresponding to accuracy required in quantifying the response wave form, storing each acquired response wave form, individually, in a format selected from the group consisting of real-time and buffered packets in digital form, and determining a total count of likely photon arrivals for a specific time resolved acquisition.

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