公开(公告)号：US12053532B2

公开(公告)日：2024-08-06

申请号：US17114195

申请日：2020-12-07

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low ,  Mohammad Noshi

IPC: A61K51/00 ,  A61B5/00 ,  A61K49/00 ,  A61M36/14 ,  G01N33/574 ,  G01N33/58

CPC classification number: A61K49/0052 ,  A61B5/0071 ,  A61K49/0032 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/57449 ,  G01N33/582

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US20210093737A1

公开(公告)日：2021-04-01

申请号：US17114195

申请日：2020-12-07

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low ,  Mohammad Noshi

IPC: A61K49/00 ,  A61B5/00 ,  G01N33/574 ,  G01N33/58

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US20170217996A1

公开(公告)日：2017-08-03

申请号：US15478276

申请日：2017-04-04

Applicant: Purdue Research Foundation

Inventor： Philip L. Fuchs ,  Mohammad Noshi

IPC: C07F7/18 ,  C07C317/12

CPC classification number: C07F7/1804 ,  C07C317/12 ,  C07C319/14 ,  C07C319/20 ,  C07C2601/18 ,  C07C323/65

Abstract: The invention relates to processes for large-scale diastereoselective syntheses of cycloheptadienylsulfone and stereotetrads, key intermediates for the preparation of Aplyronine A.