公开(公告)号：US20240390505A1

公开(公告)日：2024-11-28

申请号：US18687785

申请日：2022-08-30

Applicant: Purdue Research Foundation

Inventor： Philip Stewart LOW ,  John Victor NAPOLEON

IPC: A61K47/55 ,  A61K39/00 ,  A61K47/60

Abstract: Chimeric antigen receptor (CAR) T-cell-rejuvenating conjugates and compositions and methods of use to rejuvenate exhausted CAR T-cells.

公开(公告)号：US20240148880A1

公开(公告)日：2024-05-09

申请号：US18392939

申请日：2023-12-21

Applicant: Purdue Research Foundation

Inventor： Philip Stewart LOW ,  Boning Zhang ,  John V. Napoleon

IPC: A61K47/55 ,  A61K31/437 ,  A61K31/4535 ,  A61K31/4545 ,  A61K31/7076 ,  A61K47/62 ,  A61K47/68 ,  A61K49/00

CPC classification number: A61K47/55 ,  A61K31/437 ,  A61K31/4535 ,  A61K31/4545 ,  A61K31/7076 ,  A61K47/62 ,  A61K47/6835 ,  A61K49/0043 ,  A61K49/0052

Abstract: A payload of drug conjugated to a targeting ligand specifically designed to deliver to exhausted CAR T cells to rejuvenate these CAR T cells is provided herein. The targeted CAR T cells are modified with a fusion receptor which can bind to the targeting ligand and internalize the conjugated payload of drug to execute its regulatory function to exhausted CAR T cell.

公开(公告)号：US20220175875A1

公开(公告)日：2022-06-09

申请号：US17524211

申请日：2021-11-11

Applicant: ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION

Inventor： Yingjuan J. LU ,  Leroy W. WHEELER, II ,  Philip Stewart LOW ,  Christopher Paul LEAMON

IPC: A61K38/08 ,  A61K49/00 ,  A61K47/55 ,  A61K47/54 ,  G01N33/574

Abstract: Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.

公开(公告)号：US20220105208A1

公开(公告)日：2022-04-07

申请号：US17553113

申请日：2021-12-16

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart LOW ,  Jyoti ROY

IPC: A61K51/04 ,  A61K47/55 ,  A61K49/00 ,  G01N33/569

Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for imaging cancer-associated fibroblasts (CAFs) in the tumor microenvironment of a patient. The present teachings relate generally to method of making conjugates comprising a fibroblast activation protein (FAP) inhibitor.

公开(公告)号：US20240415921A1

公开(公告)日：2024-12-19

申请号：US18823426

申请日：2024-09-03

Applicant: ENDOCYTE, INC. ,  Purdue Research Foundation

Inventor： Yingjuan J. LU ,  Leroy W. WHEELER, II ,  Philip Stewart LOW ,  Christopher Paul LEAMON

IPC: A61K38/08 ,  A61K47/54 ,  A61K47/55 ,  A61K49/00 ,  G01N33/574

Abstract: Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.

公开(公告)号：US20230399374A1

公开(公告)日：2023-12-14

申请号：US18033665

申请日：2021-08-26

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart LOW ,  Stewart A. LOW ,  Jeffrey Jay Howard NIELSEN

IPC: C07K14/635 ,  A61K38/28 ,  C07K7/04 ,  A61P19/10

CPC classification number: C07K14/635 ,  A61K38/28 ,  C07K7/04 ,  A61P19/10

Abstract: Osteotropic ligand-bone anabolic agent compounds and related compositions and methods of use to treat bone fractures.

公开(公告)号：US20210346431A1

公开(公告)日：2021-11-11

申请号：US16971801

申请日：2019-02-22

Applicant: ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION ,  SEATTLE CHILDREN'S HOSPITAL (DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE

Inventor： Richard MESSMANN ,  Christopher Paul LEAMON ,  Haiyan CHU ,  Yingjuan June LU ,  Philip Stewart LOW ,  Michael C. JENSEN ,  James MATTHAEI ,  Navin Robert Charles PINTO ,  Julie Ruggieri PARK

IPC: A61K35/17 ,  C07K14/705 ,  A61K47/55 ,  A61P35/00

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US20200023009A1

公开(公告)日：2020-01-23

申请号：US16489455

申请日：2018-02-28

Applicant: ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart LOW ,  Haiyan CHU ,  Yong Gu LEE ,  Yingjuan J. LU ,  Christopher Paul LEAMON ,  Leroy W. WHEELER, II

IPC: A61K35/17 ,  C07K14/705 ,  C07K16/30

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US20190365904A1

公开(公告)日：2019-12-05

申请号：US16469906

申请日：2017-12-13

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart LOW ,  Jyoti ROY

IPC: A61K47/54 ,  A61K47/65 ,  A61K45/06 ,  A61K38/09 ,  A61P35/00 ,  A61K49/00

Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.

公开(公告)号：US20140234866A1

公开(公告)日：2014-08-21

申请号：US14187844

申请日：2014-02-24

Applicant: Purdue Research Foundation

Inventor： Philip Stewart LOW ,  Wei HE ,  Sumith A. KULARATNE

IPC: G01N33/58

CPC classification number: G01N33/582 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/5091 ,  G01N33/574 ,  G01N33/57434 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2458/00

Abstract: The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.

Abstract translation: 本发明涉及诊断由致病细胞介导的疾病状态的方法。 该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及 使用流式细胞术检测表达配体受体的致病细胞。