公开(公告)号：US20140234866A1

公开(公告)日：2014-08-21

申请号：US14187844

申请日：2014-02-24

Applicant: Purdue Research Foundation

Inventor： Philip Stewart LOW ,  Wei HE ,  Sumith A. KULARATNE

IPC: G01N33/58

CPC classification number: G01N33/582 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/5091 ,  G01N33/574 ,  G01N33/57434 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2458/00

Abstract: The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.

Abstract translation: 本发明涉及诊断由致病细胞介导的疾病状态的方法。 该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及 使用流式细胞术检测表达配体受体的致病细胞。

公开(公告)号：US20230293497A1

公开(公告)日：2023-09-21

申请号：US17991013

申请日：2022-11-21

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

CPC classification number: A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/0041 ,  A61K49/0043 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K47/542 ,  A61K47/548 ,  A61K49/0056 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K49/0052 ,  A61K51/088 ,  A61K47/64 ,  A61K47/547

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180271990A1

公开(公告)日：2018-09-27

申请号：US15990152

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K47/64 ,  A61K31/426 ,  A61K49/00 ,  A61K31/475 ,  C07D207/416 ,  C07C323/52 ,  C07K5/08 ,  A61K51/04 ,  A61K31/4745 ,  A61K47/54 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180271988A1

公开(公告)日：2018-09-27

申请号：US15990083

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K47/64 ,  A61K31/426 ,  A61K49/00 ,  A61K31/475 ,  C07D207/416 ,  C07C323/52 ,  C07K5/08 ,  A61K51/04 ,  A61K31/4745 ,  A61K47/54 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20170258923A1

公开(公告)日：2017-09-14

申请号：US15606913

申请日：2017-05-26

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K31/4745 ,  A61K51/04 ,  C07K5/08 ,  A61K31/426 ,  C07D207/416 ,  A61K31/475 ,  A61K51/08 ,  A61K49/00 ,  C07C323/52

CPC classification number: A61K47/64 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/54 ,  A61K47/542 ,  A61K47/547 ,  A61K47/548 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K51/088 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20160067341A1

公开(公告)日：2016-03-10

申请号：US14794482

申请日：2015-11-23

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K47/48 ,  A61K31/475 ,  A61K51/08 ,  A61K31/4745 ,  A61K31/426 ,  A61K49/00

CPC classification number: A61K47/64 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/54 ,  A61K47/542 ,  A61K47/547 ,  A61K47/548 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K51/088 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract translation: 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。

公开(公告)号：US20180289829A1

公开(公告)日：2018-10-11

申请号：US15990144

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K47/64 ,  C07D207/416 ,  A61K49/00 ,  A61K47/54 ,  A61K31/4745 ,  A61K31/426 ,  A61K51/08 ,  A61K31/475 ,  C07K5/08 ,  A61K51/04 ,  C07C323/52

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180289828A1

公开(公告)日：2018-10-11

申请号：US15990136

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K47/64 ,  C07D207/416 ,  A61K49/00 ,  A61K47/54 ,  A61K31/4745 ,  A61K31/426 ,  A61K51/08 ,  A61K31/475 ,  C07K5/08 ,  A61K51/04 ,  C07C323/52

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180289827A1

公开(公告)日：2018-10-11

申请号：US15990111

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K47/64 ,  C07D207/416 ,  A61K49/00 ,  A61K47/54 ,  A61K31/426 ,  A61K31/4745 ,  A61K51/08 ,  A61K31/475 ,  C07K5/08 ,  A61K51/04 ,  C07C323/52

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20180271989A1

公开(公告)日：2018-09-27

申请号：US15990095

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Sumith A. KULARATNE

IPC: A61K47/64 ,  A61K31/426 ,  A61K49/00 ,  A61K31/475 ,  C07D207/416 ,  C07C323/52 ,  C07K5/08 ,  A61K51/04 ,  A61K31/4745 ,  A61K47/54 ,  A61K51/08

CPC classification number: A61K47/64 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/54 ,  A61K47/542 ,  A61K47/547 ,  A61K47/548 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K51/088 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.