公开(公告)号：US20210206820A1

公开(公告)日：2021-07-08

申请号：US17058887

申请日：2019-05-30

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Stewart A. Low ,  Jeffery Jay Howard Nielsen ,  Mingding Wang

IPC: C07K14/51 ,  A61K47/64 ,  C07K14/78

Abstract: Aspects of the disclosure include material and methods for the targeted delivery of growth factors, vasoactive peptides and other representative anabolic peptide drugs from different signaling cascades to bone fracture for accelerated healing is disclosed herein. Aspects of the disclosure can be used to treat bone fractures and bone defects.

公开(公告)号：US10960054B2

公开(公告)日：2021-03-30

申请号：US16836366

申请日：2020-03-31

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Stewart A. Low ,  Jeffery Jay Howard Nielsen

IPC: A61K38/29 ,  A61P19/08 ,  A61K9/00 ,  A61P19/10 ,  C07K14/635 ,  A61K38/00

Abstract: Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite. This system offsets some side effects caused by free anabolic drug, such as high blood calcium concentration

公开(公告)号：US20210214408A1

公开(公告)日：2021-07-15

申请号：US17058884

申请日：2019-05-30

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Stewart A. Low ,  Jeffery Jay Howard Nielsen

IPC: C07K14/51 ,  C07K14/65 ,  C07K14/50 ,  C07K14/79 ,  C07K14/575 ,  C07K14/47 ,  C12N9/74 ,  C07K14/49 ,  C12N9/12 ,  C12N9/54

Abstract: The targeted delivery of growth factors, vasoactive peptides and other representative anabolic peptide drugs from different signaling cascades to bone fracture for accelerated healing is disclosed herein.

公开(公告)号：US20210213135A1

公开(公告)日：2021-07-15

申请号：US17058891

申请日：2019-05-30

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Stewart A. Low ,  Jeffery Jay Howard Nielsen

IPC: A61K47/64 ,  A61K47/60 ,  A61K38/18

Abstract: Aspects of the disclosure include materials and methods for the targeted delivery of growth factors, and other compounds that stimulate bone growth and in some aspect bone healing. Some aspects of the disclosure include methods for synthesizing and testing these compounds. Some aspects of the invention include methods of using the compounds disclosed herein to treat bone fractures and bone defects.

公开(公告)号：US20200316174A1

公开(公告)日：2020-10-08

申请号：US16836366

申请日：2020-03-31

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Stewart A. Low ,  Jeffery Jay Howard Nielsen

IPC: A61K38/29 ,  A61K9/00 ,  A61P19/08

Abstract: Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite. This system offsets some side effects caused by free anabolic drug, such as high blood calcium concentration