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公开(公告)号：US20240122927A1
公开(公告)日：2024-04-18
申请号：US18528976
申请日：2023-12-05
Applicant: Francesco Turrini , Antonella Pantaleo , Purdue Research Foundation
Inventor： Philip Stewart Low , Francesco Turrini , Antonella Pantaleo
IPC: A61K31/506 , A61K31/505
CPC classification number: A61K31/506 , A61K31/505
Abstract: The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (SYK). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one SYK inhibitor. In some embodiments the method includes repeatedly administering the SYK kinase inhibitor to a patient.
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公开(公告)号：US20230346752A1
公开(公告)日：2023-11-02
申请号：US18181487
申请日：2023-03-09
Applicant: Purdue Research Foundation
Inventor： Philip Stewart Low , Sumit A. Kularatne
IPC: A61K31/426 , C07C323/52 , C07D207/416 , A61K47/54 , A61K49/00 , A61K51/04 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K51/08 , A61K47/64
CPC classification number: A61K31/426 , C07C323/52 , C07D207/416 , A61K47/54 , A61K49/0041 , A61K49/0043 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K47/542 , A61K47/548 , A61K49/0056 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K49/0052 , A61K51/088 , A61K47/64 , A61K47/547
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
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公开(公告)号：US11759480B2
公开(公告)日：2023-09-19
申请号：US16921400
申请日：2020-07-06
Applicant: ENDOCYTE, INC. , PURDUE RESEARCH FOUNDATION
Inventor： Philip Stewart Low , Haiyan Chu , Yong Gu Lee , Yingjuan J. Lu , Christopher Paul Leamon , Leroy W Wheeler, II
IPC: A61K35/17 , C07K14/705 , C07K16/30
CPC classification number: A61K35/17 , C07K14/70503 , C07K16/30 , C07K2317/622 , C07K2319/03 , C07K2319/033
Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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公开(公告)号：US11717514B2
公开(公告)日：2023-08-08
申请号：US17086063
申请日：2020-10-30
Applicant: Purdue Research Foundation
Inventor： Philip Stewart Low , Sumith A. Kularatne
IPC: A61K31/426 , A61K47/54 , A61K49/00 , C07K5/08 , A61K31/4745 , A61K31/475 , A61K47/64 , C07C323/52 , C07D207/416 , A61K51/04 , A61K51/08
CPC classification number: A61K31/426 , A61K31/475 , A61K31/4745 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K47/64 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
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公开(公告)号：US20210214408A1
公开(公告)日：2021-07-15
申请号：US17058884
申请日：2019-05-30
Applicant: Purdue Research Foundation
Inventor： Philip Stewart Low , Stewart A. Low , Jeffery Jay Howard Nielsen
IPC: C07K14/51 , C07K14/65 , C07K14/50 , C07K14/79 , C07K14/575 , C07K14/47 , C12N9/74 , C07K14/49 , C12N9/12 , C12N9/54
Abstract: The targeted delivery of growth factors, vasoactive peptides and other representative anabolic peptide drugs from different signaling cascades to bone fracture for accelerated healing is disclosed herein.
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Patent Agency Ranking
公开(公告)号：US20210213135A1
公开(公告)日：2021-07-15
申请号：US17058891
申请日：2019-05-30
Applicant: Purdue Research Foundation
Inventor： Philip Stewart Low , Stewart A. Low , Jeffery Jay Howard Nielsen
Abstract: Aspects of the disclosure include materials and methods for the targeted delivery of growth factors, and other compounds that stimulate bone growth and in some aspect bone healing. Some aspects of the disclosure include methods for synthesizing and testing these compounds. Some aspects of the invention include methods of using the compounds disclosed herein to treat bone fractures and bone defects.
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公开(公告)号：US20200283748A1
公开(公告)日：2020-09-10
申请号：US16724729
申请日：2019-12-23
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Philip Stewart Low , Venkatesh Chelvam , Youngsoon Kim , Sumith A. Kularatne
IPC: C12N9/48 , A61K31/454 , A61K31/4745 , A61K31/475 , C12N9/96 , A61K49/00 , A61K51/04 , A61K47/54
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
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公开(公告)号：US10557128B2
公开(公告)日：2020-02-11
申请号：US15934974
申请日：2018-03-24
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Philip Stewart Low , Venkatesh Chelvam , Youngsoon Kim , Sumith A. Kularatne
IPC: C12N9/48 , A61K31/454 , A61K31/4745 , A61K31/475 , C12N9/96 , A61K49/00 , A61K51/04 , A61K47/54 , A61K38/00
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
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公开(公告)号：US09951324B2
公开(公告)日：2018-04-24
申请号：US15018068
申请日：2016-02-08
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Philip Stewart Low , Venkatesh Chelvam , Youngsoon Kim , Sumith A. Kularatne
IPC: A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12N9/48 , A61K31/454 , A61K31/4745 , A61K31/475 , C12N9/96 , A61K49/00 , A61K51/04 , A61K47/54
CPC classification number: C12N9/485 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K38/00 , A61K47/542 , A61K49/0032 , A61K49/0052 , A61K51/0402 , C12N9/96 , C12Y304/17021
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
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公开(公告)号：US20160151508A1
公开(公告)日：2016-06-02
申请号：US15018068
申请日：2016-02-08
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Philip Stewart Low , Venkatesh Chelvam , Youngsoon Kim , Sumith A. Kularatne
IPC: A61K47/48 , A61K51/08 , A61K49/00 , C12N9/48 , A61K38/15 , A61K31/4745 , A61K31/475 , C12N9/96 , A61K39/00 , A61K31/454
CPC classification number: C12N9/485 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K38/00 , A61K47/542 , A61K49/0032 , A61K49/0052 , A61K51/0402 , C12N9/96 , C12Y304/17021
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Abstract translation: 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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