公开(公告)号：US20140316108A1

公开(公告)日：2014-10-23

申请号：US14355595

申请日：2012-11-01

Applicant: Purdue Research Foundation

Inventor： Mary J. Wirth ,  Yirmin Hua ,  Zhaorui Zhang

IPC: C07K1/22 ,  B01J20/281 ,  C07H1/08

CPC classification number: C07H1/08 ,  B01D15/3809 ,  B01D15/3823 ,  B01D15/3828 ,  B01J20/103 ,  B01J20/28016 ,  B01J20/281 ,  B01J20/283 ,  B01J20/285 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3276 ,  C07K1/22

Abstract: A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of biomarker molecules from biological samples.

Abstract translation: 丙烯酰胺和第二单体的无规共聚物的涂层，例如。 描述了二氧化硅表面的甲基丙烯酸缩水甘油酯。 将涂层施加到具有二氧化硅基表面的色谱支撑结构上。 该涂层被功能化以产生蛋白质色谱基质，其特别可用于从生物样品中提取痕量的生物标记分子。

公开(公告)号：US09758542B2

公开(公告)日：2017-09-12

申请号：US14355595

申请日：2012-11-01

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Mary J. Wirth ,  Yimin Hua ,  Zhaorui Zhang

IPC: C07K1/22 ,  B01J20/281 ,  C07H1/08 ,  B01D15/38 ,  B01J20/283 ,  B01J20/285 ,  B01J20/32 ,  B01J20/10 ,  B01J20/28

CPC classification number: C07H1/08 ,  B01D15/3809 ,  B01D15/3823 ,  B01D15/3828 ,  B01J20/103 ,  B01J20/28016 ,  B01J20/281 ,  B01J20/283 ,  B01J20/285 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3276 ,  C07K1/22

Abstract: A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of biomarker molecules from biological samples.