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公开(公告)号：US20210299666A1
公开(公告)日：2021-09-30
申请号：US17183691
申请日：2021-02-24
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei
Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.
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公开(公告)号：US11139157B2
公开(公告)日：2021-10-05
申请号：US16885540
申请日：2020-05-28
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei , David G. Mclaren
Abstract: The invention generally relates to systems including nanoelectrospray ionization emitters in a movable array format in which the emitters can be loaded, singly or simultaneously, through their narrow ends using a novel dip and go method based on capillary action, taking up sample from an array. The sample solutions in each emitter can be electrophoretically cleaned, singly or simultaneously, by creating an inductive electric field that moves interfering ions away from the narrow end of the capillary. Subsequent to cleaning, the emitters are supplied with an inductive electric field that causes electrospray into a mass spectrometer allowing mass analysis of the contents of the emitter.
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Patent Agency Ranking
公开(公告)号：US11715633B2
公开(公告)日：2023-08-01
申请号：US17464135
申请日：2021-09-01
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei , David G. McLaren
CPC classification number: H01J49/167 , H01J49/0409 , H01J49/0431
Abstract: The invention generally relates to systems including nanoelectrospray ionization emitters in a movable array format in which the emitters can be loaded, singly or simultaneously, through their narrow ends using a novel dip and go method based on capillary action, taking up sample from an array. The sample solutions in each emitter can be electrophoretically cleaned, singly or simultaneously, by creating an inductive electric field that moves interfering ions away from the narrow end of the capillary. Subsequent to cleaning, the emitters are supplied with an inductive electric field that causes electrospray into a mass spectrometer allowing mass analysis of the contents of the emitter.
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公开(公告)号：US20220028676A1
公开(公告)日：2022-01-27
申请号：US17464135
申请日：2021-09-01
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei , David G. McLaren
Abstract: The invention generally relates to systems including nanoelectrospray ionization emitters in a movable array format in which the emitters can be loaded, singly or simultaneously, through their narrow ends using a novel dip and go method based on capillary action, taking up sample from an array. The sample solutions in each emitter can be electrophoretically cleaned, singly or simultaneously, by creating an inductive electric field that moves interfering ions away from the narrow end of the capillary. Subsequent to cleaning, the emitters are supplied with an inductive electric field that causes electrospray into a mass spectrometer allowing mass analysis of the contents of the emitter.
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公开(公告)号：US20250041870A1
公开(公告)日：2025-02-06
申请号：US18921948
申请日：2024-10-21
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei
Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.
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公开(公告)号：US12157126B2
公开(公告)日：2024-12-03
申请号：US17183691
申请日：2021-02-24
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei
Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.
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公开(公告)号：US20200381238A1
公开(公告)日：2020-12-03
申请号：US16885540
申请日：2020-05-28
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei , David G. Mclaren
Abstract: The invention generally relates to systems including nanoelectrospray ionization emitters in a movable array format in which the emitters can be loaded, singly or simultaneously, through their narrow ends using a novel dip and go method based on capillary action, taking up sample from an array. The sample solutions in each emitter can be electrophoretically cleaned, singly or simultaneously, by creating an inductive electric field that moves interfering ions away from the narrow end of the capillary. Subsequent to cleaning, the emitters are supplied with an inductive electric field that causes electrospray into a mass spectrometer allowing mass analysis of the contents of the emitter.
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