公开(公告)号：US20170007158A1

公开(公告)日：2017-01-12

申请号：US14795529

申请日：2015-07-09

Applicant: RAINBOW MEDICAL LTD.

Inventor： Yossi GROSS ,  Yehuda ZADOK ,  Yoel ATLACEVITZ

IPC: A61B5/06 ,  A61B18/14 ,  A61B5/0215 ,  A61B5/00

CPC classification number: A61B5/063 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/0422 ,  A61B5/068 ,  A61B5/201 ,  A61B5/6858 ,  A61B5/6885 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/7475 ,  A61B18/1492 ,  A61B2017/00026 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00666 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2090/065

Abstract: A method includes disposing at least one pair of electrodes in or on a body of a subject, including disposing at least one intrarenal electrode of the pair in a renal artery. Control circuitry is activate to (a) apply electrical pulses between the pair of electrodes, (b) calculate at least one time-varying component of electrode-tissue impedance based on applying the pulses, (c) sense a periodic hemodynamic signal of the subject, (d) calculate a level of correlation between the at least one time-varying component of the electrode-tissue impedance and the periodic hemodynamic signal, and (e) based on the level of correlation, ascertain a level of contact between the at least one intrarenal electrodes and a wall of the renal artery. In response to the level of contact being less than a threshold level of contact, a disposition of the at least one intrarenal electrodes in the renal artery is adjusted.

Abstract translation: 一种方法包括将至少一对电极设置在受试者的身体内或身体上，包括在肾动脉中设置该对的至少一个肾内电极。 控制电路被激活以（a）在一对电极之间施加电脉冲，（b）基于施加脉冲计算电极组织阻抗的至少一个时变分量，（c）感测受试者的周期性血液动力学信号 ，（d）计算电极组织阻抗的至少一个时变分量与周期性血液动力学信号之间的相关程度，以及（e）基于相关度，确定至少 一个肾内电极和肾动脉壁。 响应于接触水平小于阈值接触水平，调整肾动脉中的至少一个肾内电极的布置。

公开(公告)号：US20160324572A1

公开(公告)日：2016-11-10

申请号：US15147081

申请日：2016-05-05

Applicant: RAINBOW MEDICAL LTD.

Inventor： Yossi GROSS ,  Yehuda ZADOK

IPC: A61B18/14 ,  A61B18/12

CPC classification number: A61B18/1492 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/4848 ,  A61B5/6852 ,  A61B18/1206 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00773 ,  A61B2090/064 ,  A61B2505/05 ,  A61B2562/0247

Abstract: A method is provided, comprising: (1) applying an excitatory current to renal nerve fibers of a subject; (2) determining a change in a parameter of the subject in response to the excitatory current, the parameter being a fastest rate of increase in arterial pressure during a systolic upstroke of an arterial pressure wave of the subject; (3) in response to the change, deciding whether to ablate the renal nerve fibers; and (4) in response to the deciding, applying ablation energy to the renal nerve fibers. Other embodiments are also described.

Abstract translation: 提供了一种方法，包括：（1）向受试者的肾神经纤维施加兴奋性电流; （2）响应于兴奋性电流确定受试者的参数的变化，该参数是受试者的动脉压波的收缩期上升中行动压力的最快增加速率; （3）响应变化，决定是否消融肾神经纤维; （4）响应决定，向肾神经纤维施加消融能量。 还描述了其它实施例。

公开(公告)号：US20180055557A1

公开(公告)日：2018-03-01

申请号：US15254494

申请日：2016-09-01

Applicant: RAINBOW MEDICAL LTD.

Inventor： Yossi GROSS ,  Yehuda ZADOK

IPC: A61B18/12 ,  A61B18/14

CPC classification number: A61B18/1233 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00732 ,  A61B2018/00761 ,  A61B2018/00845 ,  A61B2018/00886 ,  A61B2018/128

Abstract: During a dual-signal period, a dual electric signal is applied at a site of a nerve of a subject, and during an ablation-signal period that is separate from the dual-signal period, an ablation electric signal is applied at the site. The dual electric signal has an excitation component and an ablation component, and the ablation electric signal has the ablation component but not the excitation component. Other embodiments are also described.

公开(公告)号：US20170172651A1

公开(公告)日：2017-06-22

申请号：US14972756

申请日：2015-12-17

Applicant: RAINBOW MEDICAL LTD.

Inventor： Yossi GROSS ,  Yehuda ZADOK ,  Assaf Israel Pele LEON

IPC: A61B18/14

Abstract: A method is described, including: (i) advancing a catheter to a first portion of a renal artery, the catheter having a plurality of electrodes coupled thereto; (ii) using one or more of the electrodes to apply ablating energy at a first portion of the renal artery; (iii) using one or more of the electrodes to apply excitatory current at a second portion of the renal artery that is at or efferent to the first portion; (iv) using a physiological sensor, sensing that a physiological response to the excitatory current is below a threshold response; (v) subsequently, advancing the catheter distally, and (vi) subsequently, using one or more of the electrodes to apply ablating energy at a third portion of the renal artery that is the same as or efferent to the second portion. Other embodiments are also described.

公开(公告)号：US20170007157A1

公开(公告)日：2017-01-12

申请号：US14794737

申请日：2015-07-08

Applicant: RAINBOW MEDICAL LTD.

Inventor： Yossi GROSS ,  Yehuda ZADOK ,  Assaf Israel Pele LEON

IPC: A61B5/06 ,  A61B5/0245 ,  A61B5/00 ,  A61B18/14 ,  A61B5/042

CPC classification number: A61B5/063 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/0422 ,  A61B5/068 ,  A61B5/201 ,  A61B5/6858 ,  A61B5/6885 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/7475 ,  A61B18/1492 ,  A61B2017/00026 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00666 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2090/065

Abstract: A method includes disposing a pair of current-application electrodes in or on a body, including disposing an intrarenal current-application electrode of the pair in a renal artery. Two or more sensing electrodes are disposed in or on the body, including disposing one of the sensing electrodes on en external surface of skin. Control circuitry is activated to (a) apply an electrical current between the pair of current-application electrodes, (b) while applying the electrical current, sense an electrical signal between the sensing electrodes, including the sensing electrode disposed on the external surface of the skin, and (c) based on the electrical signal, ascertain a level of contact between the intrarenal current-application electrode and a wall of the renal artery. In response to the level of contact being less than a threshold level of contact, a disposition of the intrarenal current-application electrode in the renal artery is adjusted.

Abstract translation: 一种方法包括在身体内或身体上设置一对电流施加电极，包括在肾动脉中设置该对的肾内电流施加电极。 两个或更多个感测电极设置在身体中或身上，包括将一个感测电极设置在皮肤的外表面上。 控制电路被激活以（a）在一对电流施加电极之间施加电流，（b）在施加电流的同时，感测电极之间的电信号，包括设置在电流施加电极的外表面上的感测电极 皮肤和（c）基于电信号，确定肾内电流施加电极与肾动脉壁之间的接触程度。 响应于接触水平小于阈值接触水平，调整肾内电流施加电极在肾动脉中的布置。