公开(公告)号：US20170007158A1

公开(公告)日：2017-01-12

申请号：US14795529

申请日：2015-07-09

Applicant: RAINBOW MEDICAL LTD.

Inventor： Yossi GROSS ,  Yehuda ZADOK ,  Yoel ATLACEVITZ

IPC: A61B5/06 ,  A61B18/14 ,  A61B5/0215 ,  A61B5/00

CPC classification number: A61B5/063 ,  A61B5/0215 ,  A61B5/0245 ,  A61B5/0422 ,  A61B5/068 ,  A61B5/201 ,  A61B5/6858 ,  A61B5/6885 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/7475 ,  A61B18/1492 ,  A61B2017/00026 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00666 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2090/065

Abstract: A method includes disposing at least one pair of electrodes in or on a body of a subject, including disposing at least one intrarenal electrode of the pair in a renal artery. Control circuitry is activate to (a) apply electrical pulses between the pair of electrodes, (b) calculate at least one time-varying component of electrode-tissue impedance based on applying the pulses, (c) sense a periodic hemodynamic signal of the subject, (d) calculate a level of correlation between the at least one time-varying component of the electrode-tissue impedance and the periodic hemodynamic signal, and (e) based on the level of correlation, ascertain a level of contact between the at least one intrarenal electrodes and a wall of the renal artery. In response to the level of contact being less than a threshold level of contact, a disposition of the at least one intrarenal electrodes in the renal artery is adjusted.

Abstract translation: 一种方法包括将至少一对电极设置在受试者的身体内或身体上，包括在肾动脉中设置该对的至少一个肾内电极。 控制电路被激活以（a）在一对电极之间施加电脉冲，（b）基于施加脉冲计算电极组织阻抗的至少一个时变分量，（c）感测受试者的周期性血液动力学信号 ，（d）计算电极组织阻抗的至少一个时变分量与周期性血液动力学信号之间的相关程度，以及（e）基于相关度，确定至少 一个肾内电极和肾动脉壁。 响应于接触水平小于阈值接触水平，调整肾动脉中的至少一个肾内电极的布置。