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    METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR ION RADIOTHERAPY
    1.
    发明申请
    METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR ION RADIOTHERAPY 审中-公开

    公开(公告)号：US20200086142A1

    公开(公告)日：2020-03-19

    申请号：US16599546

    申请日：2019-10-11

    Applicant: RaySearch Laboratories AB

    Inventor： Erik TRANEUS

    IPC: A61N5/10

    Abstract: A method of performing dose calculations for ion radiotherapy compensating for tissue in which the density within a voxel may be inhomogeneous by approximating a portion of the voxel as an air cavity. For each dose voxel, the voxel is inscribed in a three-dimensional grid comprising a number of cells and the propagation of ions through the voxel is calculated based on the cell pattern in the at least one cell overlapping the voxel. Preferably, the voxel is inscribed in the three-dimensional grid in such a way that it overlaps at least one cell fully. Each cell comprises a first portion representing a first density corresponding to a density of a tissue and a second portion representing a second density corresponding to the density of air, the first and second portions forming a cell pattern.

    RADIOTHERAPY TREATMENT PLAN EVALUATION AND IMPROVEMENT
    2.
    发明申请
    RADIOTHERAPY TREATMENT PLAN EVALUATION AND IMPROVEMENT 有权

    公开(公告)号：US20250121208A1

    公开(公告)日：2025-04-17

    申请号：US18681084

    申请日：2022-06-16

    Applicant: RaySearch Laboratories AB

    Inventor： Erik TRANEUS ,  Lars GLIMELIUS ,  Erik ENGWALL ,  Elias CONIAVITIS

    IPC: A61N5/10 ,  G16H20/40

    Abstract: A radiotherapy treatment plan may be evaluated based on a combination of two or more metrics, by the steps of simulating the result of delivery of the plan, obtaining values from the simulation for at least a first and a second metric, performing a multivariate analysis of the values and determining a quality of the plan based on the result of the multivariate analysis. The metrics may include at least one of dose, LET, track ends, RBE, alpha/beta ratio and statistical uncertainty of the plan.

    TREATMENT PLANNING USING MULTIPLE RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) MODELS
    3.
    发明公开
    TREATMENT PLANNING USING MULTIPLE RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) MODELS 审中-公开

    公开(公告)号：US20230211177A1

    公开(公告)日：2023-07-06

    申请号：US17996620

    申请日：2021-04-09

    Applicant: RaySearch Laboratories AB (Publ)

    Inventor： Martin JANSON ,  Albin FREDRIKSSON ,  Erik TRANEUS ,  Kjell ERIKSSON

    IPC: A61N5/10 ,  G16H20/40

    CPC classification number: A61N5/1031 ,  G16H20/40 ,  A61N2005/1087

    Abstract: An inverse-planning method (100), by which a treatment plan specifying a non-photon irradiation of a patient including a target volume is generated, comprises: obtaining (110, 112) first and second plan goals in terms of a respective first and second numerical condition on the treatment plan’s photon-equivalent dose as computed using a first and second RBE factor; and generating (114) the treatment plan by an optimization process aiming to satisfy the first, second and any further plan goals, wherein (a) the first and second plan goals apply to volumes which either are included in the TV or are completely or partially separate from the TV and/or (b) the first and second RBE factors are variable. In a further aspect, a data carrier provides a treatment plan with these characteristics together with reporting quantities relating to fulfilment of the first and second plan goals.

    METHOD AND SYSTEM FOR ROBUST RADIOTHERAPY TREATMENT PLANNING FOR BIOLOGICAL UNCERTAINTIES
    4.
    发明申请
    METHOD AND SYSTEM FOR ROBUST RADIOTHERAPY TREATMENT PLANNING FOR BIOLOGICAL UNCERTAINTIES 有权

    公开(公告)号：US20220296925A1

    公开(公告)日：2022-09-22

    申请号：US17618088

    申请日：2020-06-02

    Applicant: RaySearch Laboratories AB

    Inventor： Minna WEDENBERG ,  Jakob ÖDÉN ,  Albin FREDRIKSSON ,  Erik TRANEUS

    IPC: A61N5/10

    Abstract: A method for generating a robust radiotherapy treatment plan for a treatment volume of a subject, the treatment volume being defined using a plurality of voxels, the method comprising the steps of defining (S100) an optimization problem using at least one optimization function for a biological endpoint related to the radiotherapy treatment; defining (S102) a set of scenarios comprising at least a first scenario and a second scenario, wherein at least two of the scenarios in the set of scenarios represent different biological models to quantify the same biological endpoint; calculating (S104) an optimization function value for each scenario in the set of scenarios; generating (S106) a radiotherapy treatment plan by robustly optimizing the optimization function value evaluated over the set of scenarios

    A METHOD AND A CORRESPONDING RADIATION TREATMENT SYSTEM FOR FACILITATING OPTIMIZATION OF A MULTIMODAL RADIATION THERAPY PLAN
    5.
    发明申请
    A METHOD AND A CORRESPONDING RADIATION TREATMENT SYSTEM FOR FACILITATING OPTIMIZATION OF A MULTIMODAL RADIATION THERAPY PLAN 有权

    公开(公告)号：US20210205635A1

    公开(公告)日：2021-07-08

    申请号：US17057170

    申请日：2019-05-27

    Applicant: RaySearch Laboratories AB

    Inventor： Rasmus BOKRANTZ ,  Albin FREDRIKSSON ,  Kjell ERIKSSON ,  Erik ENGWALL ,  Erik TRANEUS

    IPC: A61N5/10

    Abstract: The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for facilitating a multimodal radiation therapy treatment plan, in particular a multimodal radiation therapy plan employing a combined photon beam and electron beam radiation treatment. According to one example embodiment described in the disclosure, a method may comprise obtaining information related to a set of candidate beam types for the combined photon beam and electron beam radiation treatment; comparing the set of candidate beam types against a selection criterion to establish a subset of beam types from the candidate beam types; and generating the combined photon beam and electron beam radiation treatment plan utilizing the thus established subset of beam types.

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