公开(公告)号：US20240066051A1

公开(公告)日：2024-02-29

申请号：US18237624

申请日：2023-08-24

Applicant: Rensselaer Polytechnic Institute

Inventor： Robert John LINHARDT ,  Fuming ZHANG ,  Jawed FAREED ,  Walter JESKE

IPC: A61K31/737 ,  A61K9/00 ,  A61P31/14

CPC classification number: A61K31/737 ,  A61K9/0043 ,  A61P31/14

Abstract: Prophylaxis and treatment of patients susceptible to infection by coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is achieved using compositions including one or more inhibitors including sulfated glycans and/or highly negative charged compounds. The inhibitors bind to wild-type and variant spike glycoproteins (S-proteins or SGPs) of SARS-CoV-2, inhibiting fusion, entry, and infection of a host cell. The inhibitors can include pentosan polysulfate (PPS), mucopolysaccharide polysulfate (MPS), sulfated lactobionic acid, sulodexide, a defibrotide, 4-t-butylcalix[X] arene-p-sulfonic acid, or combinations thereof. The presence of additional sulfo groups in PPS and MPS contribute to the improved inhibitory activity of compositions with those sulfated glycans against COVID-19 compared with compositions containing heparin alone. The compositions can be formulated for nasal delivery to a patient, enabling a simplified treatment regimen effective against an ever increasing number of SARS-CoV-2 variants of concern.

公开(公告)号：US20220251731A1

公开(公告)日：2022-08-11

申请号：US17729388

申请日：2022-04-26

Applicant: RENSSELAER POLYTECHNIC INSTITUTE

Inventor： Ranodhi Nilochani UDANGAWA ,  Charles Frederick WILLARD ,  Chiara Diamante MANCINELLI ,  Caitlyn A. CHAPMAN ,  Robert John LINHARDT ,  Trevor John SIMMONS

IPC: D01D5/00 ,  D01D10/06 ,  D01F1/10 ,  D01F2/00 ,  D04H1/4391 ,  D01D5/34 ,  D01D5/20 ,  D04H1/728 ,  D04H1/413 ,  D04H1/4382

Abstract: A network of microfibers are fabricated with a core-shell construction from sustainable materials, where the core includes a phase-change material, such as coconut oil, and the shell includes a biomass, such as cellulose. The microfibers are made via a wet-wet electrospinning process utilizing a coaxial spinneret with an inner conduit and an outer conduit. The biomass and the phase-change material are coaxially extruded into a coagulation bath including a mixture of ethanol and water. The collected microfibers exhibit a beaded structure of PCM aggregates and biomass connecting regions between the aggregates and are effective to aid in the thermoregulation of the immediate environment surrounding the network. The microfibers are suitable for use in a variety of sustainable products such as wearable thermoregulating textiles, wall/ceiling panels, insulation, packaging material, and more.

公开(公告)号：US20250114394A1

公开(公告)日：2025-04-10

申请号：US18597050

申请日：2024-03-06

Applicant: RENSSELAER POLYTECHNIC INSTITUTE

Inventor： Robert John LINHARDT ,  So-Young Kim ,  Weihua Jin ,  Jonathan Seth Dordick ,  Fuming Zhang ,  Seok-Joon Kwon ,  Paul S. Kwon ,  Keith Fraser

IPC: A61K31/727 ,  A61K31/737 ,  A61K45/06 ,  A61P31/04

Abstract: The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) via competitive binding to SARS-COV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-COV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-COV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.

公开(公告)号：US20250090572A1

公开(公告)日：2025-03-20

申请号：US18899285

申请日：2024-09-27

Applicant: RENSSELAER POLYTECHNIC INSTITUTE

Inventor： Robert John LINHARDT ,  So-Young Kim ,  Weihua Jin ,  Jonathan Seth Dordick ,  Fuming Zhang ,  Seok-Joon Kwon ,  Paul S. Kwon ,  Keith Fraser

IPC: A61K31/737 ,  A61K31/727 ,  A61P31/14

Abstract: The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.

公开(公告)号：US20230212643A1

公开(公告)日：2023-07-06

申请号：US17612000

申请日：2020-05-18

Applicant: RENSSELAER POLYTECHNIC INSTITUTE

Inventor： Xing WANG ,  Seok-Joon KWON ,  Jonathan Seth DORDICK ,  Robert John LINHARDT ,  Paul S. KWON

IPC: C12Q1/68 ,  C12Q1/70 ,  C12N15/115

CPC classification number: C12Q1/68 ,  C12Q1/701 ,  C12N15/115 ,  C12N2310/16 ,  C12Q2600/16

Abstract: The oligonucleotide nanostructures enable pattern-recognized targeting of diseases, particularly useful as high-specificity detectors and inhibitors of viruses and toxins, such as for Dengue virus particles. The nanostructures include an oligonucleotide scaffold with a plurality of binders arranged in a pattern conforming to a plurality of surface epitopes of a target disease. Binding of the scaffolds to these surface epitopes has been shown to have inhibitory effects against the target disease. The scaffolds can also include functional domains that activate upon target binding. Assembly of the scaffolds can be achieved via annealing of separate oligonucleotide segments of predetermined length and sequence, which also advantageously define locations of binding domains in the resulting structure. This approach provides precise control over the spacing and orientation of epitope binding sites in the scaffold.

公开(公告)号：US20200255980A1

公开(公告)日：2020-08-13

申请号：US16789914

申请日：2020-02-13

Applicant: RENSSELAER POLYTECHNIC INSTITUTE

Inventor： Ranodhi Nilochani UDANGAWA ,  Charles Frederick WILLARD ,  Chiara Diamante MANCINELLI ,  Caitlyn A. CHAPMAN ,  Robert John LINHARDT ,  Trevor John SIMMONS

IPC: D01D5/00 ,  D01F1/10 ,  D01F2/00 ,  D01D10/06

Abstract: A network of microfibers are fabricated with a core-shell construction from sustainable materials, where the core includes a phase-change material, such as coconut oil, and the shell includes a biomass, such as cellulose. The microfibers are made via a wet-wet electrospinning process utilizing a coaxial spinneret with an inner conduit and an outer conduit. The biomass and the phase-change material are coaxially extruded into a coagulation bath including a mixture of ethanol and water. The collected microfibers exhibit a beaded structure of PCM aggregates and biomass connecting regions between the aggregates and are effective to aid in the thermoregulation of the immediate environment surrounding the network. The microfibers are suitable for use in a variety of sustainable products such as wearable thermoregulating textiles, wall/ceiling panels, insulation, packaging material, and more.