-
公开(公告)号：US12282694B2
公开(公告)日：2025-04-22
申请号：US17769475
申请日：2020-10-21
Applicant: Rensselaer Polytechnic Institute
Inventor： Michael Shur
Abstract: One embodiment provides a computing device. The computing device is configured to couple to a display. The computing device includes an ambient detection module configured to detect a characteristic of ambient light relative to at least a portion of a display area of the display. The computing device further includes a displayed image optimization module configured to optimize a feature of at least a portion of a displayed image based, at least in part, on the characteristic of the ambient light.
-
公开(公告)号：US20250114394A1
公开(公告)日：2025-04-10
申请号：US18597050
申请日：2024-03-06
Applicant: RENSSELAER POLYTECHNIC INSTITUTE
Inventor： Robert John LINHARDT , So-Young Kim , Weihua Jin , Jonathan Seth Dordick , Fuming Zhang , Seok-Joon Kwon , Paul S. Kwon , Keith Fraser
IPC: A61K31/727 , A61K31/737 , A61K45/06 , A61P31/04
Abstract: The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) via competitive binding to SARS-COV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-COV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-COV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.
-
公开(公告)号：US20250091017A1
公开(公告)日：2025-03-20
申请号：US18934768
申请日：2024-11-01
Applicant: Georges Belfort , Pravav Ramesh , RENSSELAER POLYTECHNIC INSTITUTE
Inventor： Georges BELFORT , Pranav Ramesh , Surya Karla , James Kilduff
Abstract: A membrane for separating organic solvents such as methanol and toluene is provided. A plurality methacrylate polymer brushes, e.g., composed of hydroxyethyl methacrylate (HEMA) monomers or aminoethyl methacrylate (AEMA) monomers, are grafted from a crosslinked polyimide support using Single Electron Transfer-Living Radical Polymerization (SET-LRP). The polymer brushes themselves are also crosslinked by ethylene glycol dimethacrylate (EGDMA), triethylene glycol dimethacryalte (TEGDMA) trimesic acid, and/or itaconic acid. These hydrophilic polymeric brush membranes demonstrate pore stiffening and yet also opening, obtaining high selectivity at reasonable permeability and reduced energy requirements for commercially relevant separations, e.g., methanol/toluene. The addition of the crosslinker prevents loss of selectivity as a result of imparting increased rigidity, enabling the membranes to be operated at higher operating pressures for increased throughput. These membranes would be beneficial for use in pharmaceutical, chemical, petroleum, food, and biotechnology industries, e.g., in the manufacture of polymethacrylic acid, the manufacture of paraxylene, etc.
-
公开(公告)号：US20250090572A1
公开(公告)日：2025-03-20
申请号：US18899285
申请日：2024-09-27
Applicant: RENSSELAER POLYTECHNIC INSTITUTE
Inventor： Robert John LINHARDT , So-Young Kim , Weihua Jin , Jonathan Seth Dordick , Fuming Zhang , Seok-Joon Kwon , Paul S. Kwon , Keith Fraser
IPC: A61K31/737 , A61K31/727 , A61P31/14
Abstract: The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μM, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.
-
公开(公告)号：US20250000761A1
公开(公告)日：2025-01-02
申请号：US18694024
申请日：2022-09-22
Inventor： Ronald Gabbard , Julie Ann Wieland , Yabin Lei , Evan Beach , Crystal Kunzel , Richard Alan Gross , Xue Wang
Abstract: This disclosure relates to biodegradable core-shell microcapsule compositions wherein the microcapsule shell contains a polymer formed with a biobased epoxide and a polyamine. This disclosure also relates to a method of preparing such biodegradable core-shell microcapsules. This disclosure also relates to consumer products containing such biodegradable core-shell microcapsules.
-
Patent Agency Ranking
公开(公告)号：US20240383214A1
公开(公告)日：2024-11-21
申请号：US18691919
申请日：2022-09-14
Applicant: Alexandros TSAMIS , Daniel F. WALCZYK , Daniel M. COHEN , RENSSELAER POLYTECHNIC INSTITUTE
Inventor： Alexandros Tsamis , Daniel F. Walczyk , Daniel M. Cohen
IPC: B29C70/52 , B29C53/02 , B29C53/32 , B29C70/54 , B29K105/10 , B29K301/12 , B29L31/06
Abstract: A system for producing rebar includes a pultruding machine configured to receive a flexible rebar preform. The flexible rebar preform includes at least one reinforcement filament, and at least one thermoplastic filament. The at least one reinforcement filament, and the at least one thermoplastic filament are arranged in a selected distribution across a cross-section of the preform. The pultruding machine includes a pulling apparatus, a rebar cutting apparatus, and a bending apparatus. The pultruding machine is configured to heat the flexible rebar preform to a first temperature. The first temperature is greater than or equal to a melt temperature of the thermoplastic filaments. The pulling apparatus is configured to pull the flexible rebar preform through a pultrusion die to form the rebar. The rebar cutting apparatus is configured to cut the rebar at a prespecified length. The bending apparatus is configured to bend the cut rebar to a prespecified bend geometry.
-
7.发明公开公开(公告)号：US20240295495A1
公开(公告)日：2024-09-05
申请号：US18388130
申请日：2023-11-08
Applicant: Rensselaer Polytechnic Institute
Inventor： Todd Michael PRZYBYCIEN , Runye Helen ZHA , Hannah Rose DOSS
CPC classification number: G01N21/6428 , C12Q1/06 , G01N33/15 , G01N2333/005 , G01N2500/20
Abstract: Evaluating viral clearance of a sample including a drug of interest is performed via modified viral surrogate nanoparticles that mimic a target live virus equivalent. The nanoparticles include fluorescent materials and a viral surface-mimicking layer that physicochemically mimics the external surface of the target live virus equivalent. One or more capsid proteins of the live virus are bound to the nanoparticle core (for non-enveloped viruses) or incorporated into a lipid bilayer (for enveloped viruses). A process solution is formed by adding the nanoparticles to the sample. The solution is subjected to purification steps to eliminate impurities, forming a product process solution. The product process solution is filtered through a dead-end flow nanofiltration membrane separator configured to bind the fluorescent nanoparticles. A load process solution is filtered as well. Baseline decomposition of the fluorescence intensity measurements from the separate membranes can, upon application of a standard curve indicate the relative nanoparticle concentration and thus the efficacy of the purification steps against the target live virus equivalent.
-
公开(公告)号：US20240070938A1
公开(公告)日：2024-02-29
申请号：US18238605
申请日：2023-08-28
Applicant: Rensselaer Polytechnic Institute
IPC: G06T11/00
CPC classification number: G06T11/008 , G06T11/005 , G06T2211/412 , G06T2211/428 , G06T2211/441
Abstract: In one embodiment, there is provided a dynamic multi-source image reconstruction apparatus. The apparatus includes a first reconstruction stage, a second reconstruction stage, and a refinement stage. The first reconstruction stage is configured to receive an input data set including a group of data frames. Each data frame corresponds to a respective time step. Each data frame includes a number of projection data sets. Each projection data set corresponds to a respective source-detector pair of a stationary multi-source tomography system. The first reconstruction stage is further configured to reconstruct a first intermediate image based, at least in part, on the group of data frames. The second reconstruction stage is configured to receive a selected data frame and to reconstruct a second intermediate image with a constraint of the first intermediate image as prior. The refinement stage is configured to refine the second intermediate image to produce a three-dimensional output image.
-
公开(公告)号：US20240047071A1
公开(公告)日：2024-02-08
申请号：US18216679
申请日：2023-06-30
Applicant: Rensselaer Polytechnic Institute
Inventor： Deepak Vashishth , Bowen Wang
CPC classification number: G16H50/30 , A61B5/7275 , A61B5/4504 , A61B5/14532
Abstract: A method of predicting bone fracture risk in a type 2 diabetes (“T2D”) patient includes: obtaining a plurality of averaged glycated hemoglobin (“HbA1c”) values for a plurality of T2D subjects over an observational period; binning the plurality of averaged HbA1c values into two predetermined categories; obtaining a plurality of total fracture incidences for the plurality of T2D subjects over a follow-up period; performing a plurality of linear regression model correlations between the binned HbA1c values and the plurality of total fracture incidences to determine a bone fracture rate prediction model; obtaining a measurement of an HbA1c value of the T2D patient; and analyzing the HbA1c value of the T2D patient with the bone fracture rate prediction model to determine the T2D patient's risk of bone fracture for a future period.
-
公开(公告)号：US11893661B2
公开(公告)日：2024-02-06
申请号：US17194946
申请日：2021-03-08
Applicant: University of Iowa Research Foundation , Shandong University , Shandong Provincial Chest Hospital , Rensselaer Polytechnic Institute
Inventor： Wenxiang Cong , Ye Yangbo , Ge Wang , Shuwei Mao , Yingmei Wang
CPC classification number: G06T11/006 , A61B6/032 , G06T11/003 , G06T11/005 , G06T2211/408 , G06T2211/424
Abstract: The disclosed apparatus, systems and methods relate to a framelet-based iterative algorithm for polychromatic CT which can reconstruct two components using a single scan. The algorithm can have various steps including a scaled-gradient descent step of constant or variant step sizes; a non-negativity step; a soft thresholding step; and a color reconstruction step.
-
-
-
-
-
-
-
-
-
Search Results
587
records
(took 0.027 seconds)
