公开(公告)号：US20190157064A1

公开(公告)日：2019-05-23

申请号：US16320627

申请日：2016-09-21

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke TATEISHI

IPC: H01J49/42 ,  G01N27/62 ,  H01J49/14

Abstract: A mass spectrometer including: an ionization chamber (11) that generates ions from a sample, a collision cell (222) located downstream from the ionization chamber (11), a mass separation unit (2412) located downstream from the collision cell (222), an energy barrier unit (223) located between the collision cell (222) and the mass separation unit (2412), a voltage application unit (30) that applies a voltage to each of the ionization chamber (11), the collision cell (222), and the energy barrier unit (223), and a control unit (42) that controls the voltage application unit (30) such that a potential of the ionization chamber (11) is set to a first potential, a potential of the collision cell (222) is set to a second potential that is lower than the first potential, and a potential of the energy barrier unit (223) is set to a third potential between the first potential and the second potential.

公开(公告)号：US20240355609A1

公开(公告)日：2024-10-24

申请号：US18635947

申请日：2024-04-15

Applicant: SHIMADZU CORPORATION

Inventor： Hiroko UEDA ,  Yusuke TATEISHI

IPC: H01J49/40 ,  H01J49/00

CPC classification number: H01J49/40 ,  H01J49/0036 ,  H01J49/0009

Abstract: A plurality of partial mass-to-charge-ratio ranges are defined so that neighboring partial mass-to-charge-ratio ranges overlap each other at a mass-to-charge ratio of a reference ion (Step 2). Mass spectrometry data of a known compound is acquired in each partial mass-to-charge-ratio range (Steps 3 and 4). A normalization coefficient is determined based on a measured intensity of the reference ion in the mass spectrometry data acquired in each of the neighboring partial mass-to-charge-ratio ranges (Steps 6 and 9). Mass spectrometry data of a measurement-target sample is acquired in each partial mass-to-charge-ratio range (Step 12). The mass spectrometry data of the measurement-target sample acquired in each partial mass-to-charge-ratio range is normalized by being multiplied by the corresponding normalization coefficient (Step 14). The normalized mass spectrometry data of the plurality of partial mass-to-charge-ratio ranges is integrated into one set of mass spectrometry data (Step 15).

公开(公告)号：US20170301531A1

公开(公告)日：2017-10-19

申请号：US15131299

申请日：2016-04-18

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke TATEISHI

IPC: H01J49/26 ,  G01N27/62

CPC classification number: G01N27/622

Abstract: An offset voltage adjusting portion is provided in an amplifying portion for applying respective pulse voltages to a pair of grid electrodes that structures a shutter gate grid. Because the pulse voltage is shifted in the direction of the voltage axis, with the amplitude and pulse width thereof maintained, when the offset voltage is adjusted, this enables a potential difference to be applied to the voltages that are applied to the front grid electrode and the rear grid electrode when the shutter gate grid is open. This potential difference produces an electric field for accelerating ions in the space between the pair of grid electrodes, thus accelerating the movement of ions immediately following the switching of the shutter gate grid from the closed state to the open state, enabling the pulse width of the ions to be narrowed.

公开(公告)号：US20210296108A1

公开(公告)日：2021-09-23

申请号：US16330640

申请日：2016-10-11

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke TATEISHI ,  Yoshihiro UENO ,  Shinji MIYAUCHI

IPC: H01J49/06 ,  H01J49/10 ,  H01J49/42

Abstract: An ion guide (222) is for use in transport of an ion incident from an upstream side toward a downstream side. The ion guide includes 2n rod electrodes (n is an integral number greater than or equal to 2) equally spaced and surrounding an ion optical axis (C) that is a central axis of a flight path of the ion, a voltage applying unit (30) that applies a radio-frequency voltage to the 2n rod electrodes, and a controller (43) that controls the voltage applying unit (30). The controller (43) prompts the voltage applying unit (30) to apply a radio-frequency voltage that generates, in a space surrounded by the 2n rod electrodes, an electric field which is a 2n-multipole electric field superimposed by a higher-order electric field component than the 2n-multipole electric field.

公开(公告)号：US20220285143A1

公开(公告)日：2022-09-08

申请号：US17632293

申请日：2020-08-11

Applicant: SHIMADZU CORPORATION

Inventor： Yoshihiro UENO ,  Ryugo MAEDA ,  Yusuke TATEISHI ,  Hiroyuki MIURA

IPC: H01J49/40 ,  H01J49/06 ,  H01J49/42

Abstract: An MT-TOFMS which is one mode of the present invention includes: a linear ion trap (2) configured to temporarily hold ions to be analyzed, and to eject the ions through an ion ejection opening (211) having a shape elongated in one direction; a loop flight section (3) configured to form a loop path (P) capable of making ions repeatedly fly; and a slit part (5) located on an ion path in which the ions ejected from the linear ion trap (2) travel until the ions are introduced into the loop path, the slit part configured to block a portion of the ions in a longitudinal direction of the ion ejection opening (211).

公开(公告)号：US20220189758A1

公开(公告)日：2022-06-16

申请号：US17466565

申请日：2021-09-03

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke TATEISHI ,  Hiroyuki MIURA ,  Hideaki IZUMI

IPC: H01J49/40 ,  H01J49/06

Abstract: Provided is a time-of-flight mass spectrometer including: a loop-orbit defining electrode (21) including an outer electrode (211) and inner electrode (212) located on the outside and inside of a loop orbit, respectively; an ion inlet (22); an ion outlet (23) provided in either the outer or inner electrode; a loop-flight voltage applier (28) configured to apply loop-flight voltages to the outer and inner electrodes, respectively; a set of deflecting electrodes (24) facing each other across a section of an n-th loop orbit, where n is a predetermined number, the deflecting electrodes including a first portion (241) which faces the n-th loop orbit and a second portion (242) which includes other portions; and a voltage applier (29) configured to apply deflecting voltages to the first portion so as to reverse the drifting direction of the ions flying in the n-th loop orbit, and a voltage to the second portion so as to create the loop-flight electric field.

公开(公告)号：US20160247669A1

公开(公告)日：2016-08-25

申请号：US15049366

申请日：2016-02-22

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke TATEISHI ,  Kazuteru TAKAHASHI ,  Hideki SATO

IPC: H01J49/14

CPC classification number: H01J49/147 ,  H01J27/024 ,  H01J27/205 ,  H01J49/067 ,  H01J49/145

Abstract: In an ion source 3 in which a repeller electrode 32 for forming a repelling electric field that repels ions toward an ion emission port 311 is provided inside of an ionization chamber 31, ion focusing electrodes 36 and 37 are respectively arranged between an electron introduction port 312 and a filament 34 and between an electron discharge port 313 and a counter filament 35. An electric field formed by applying a predetermined voltage to each of the ion focusing electrodes 36 and 37 intrudes into the ionization chamber 31 through the electron introduction port 312 and the electron discharge port 313, and becomes a focusing electric field that pushes the ions in an ion optical axis C direction. Ions at positions off a central part of the ionization chamber 31 receive the combined force of the force of the repelling electric field and the force of the focusing electric field, and move toward the ion emission port 311 while approaching the ion optical axis C. Accordingly, the amount of ions sent out from the ion emission port increases. Further, even if a charge-up phenomenon occurs, the ion trajectories less easily change, and the stability of the sensitivity can be enhanced.

Abstract translation: 在离子源3中，在电离室31的内部设置有用于形成排斥离子的排斥电极的排斥电极32，离子聚焦电极36,37分别配置在电子引入口312 灯丝34和电子排出口313和反向灯丝35之间。通过向每个离子聚焦电极36和37施加预定电压而形成的电场通过电子引入口312侵入电离室31和 电子放电端口313，并且成为在离子光轴C方向推动离子的聚焦电场。 在离子化室31的中心部分的位置处的离子接收排斥电场的力和聚焦电场的力的组合力，并且在接近离子光轴C的同时向离子发射端口311移动。因此 从离子发射口发出的离子量增加。 此外，即使发生充电现象，离子轨迹也不容易改变，并且可以提高灵敏度的稳定性。