公开(公告)号：US20240209041A1

公开(公告)日：2024-06-27

申请号：US18390354

申请日：2023-12-20

Applicant: SRI International

Inventor： Kathlynn C. Brown ,  Nathan Collins ,  Shunzi "Susan" Li ,  Curtis Allred ,  Keen Chung ,  Michael McGuire

IPC: C07K14/47 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K14/4702 ,  A61K47/64 ,  A61P35/00 ,  C07K16/2803 ,  A61K38/00

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

公开(公告)号：US20220227823A1

公开(公告)日：2022-07-21

申请号：US16629799

申请日：2018-07-10

Applicant: SRI INTERNATIONAL

Inventor： Kathlynn C. Brown ,  Nathan Collins ,  Shunzi "Susan" Li ,  Curtis Allred ,  Keen Chung ,  Michael McGuire

IPC: C07K14/47 ,  A61K47/64 ,  C07K16/28 ,  A61P35/00

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

公开(公告)号：US20220226487A1

公开(公告)日：2022-07-21

申请号：US16629803

申请日：2018-07-10

Applicant: SRI INTERNATIONAL

Inventor： Kathlynn C. Brown ,  Curtis Allred ,  Michael McGuire

IPC: A61K47/64 ,  A61P35/00 ,  A61K38/16 ,  A61K47/60 ,  A61K45/06

Abstract: Disclosed herein, are compositions comprising one or more molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer.

公开(公告)号：US11965004B2

公开(公告)日：2024-04-23

申请号：US16629799

申请日：2018-07-10

Applicant: SRI INTERNATIONAL

Inventor： Kathlynn C. Brown ,  Nathan Collins ,  Shunzi “Susan” Li ,  Curtis Allred ,  Keen Chung ,  Michael McGuire

IPC: C07K14/47 ,  A61K47/64 ,  A61P35/00 ,  C07K16/28 ,  A61K38/00

CPC classification number: C07K14/4702 ,  A61K47/64 ,  A61P35/00 ,  C07K16/2803 ,  A61K38/00

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

公开(公告)号：US20240024495A1

公开(公告)日：2024-01-25

申请号：US18352791

申请日：2023-07-14

Applicant: SRI International

Inventor： Kathlynn C. Brown ,  Curtis Allred ,  Michael McGuire

IPC: A61K47/64 ,  A61K47/60 ,  A61P35/00 ,  A61K38/16 ,  A61K45/06

CPC classification number: A61K47/6415 ,  A61K47/60 ,  A61P35/00 ,  A61K38/168 ,  A61K45/06

Abstract: Disclosed herein, are compositions comprising one or more a molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer.

公开(公告)号：US20220380764A1

公开(公告)日：2022-12-01

申请号：US17766109

申请日：2020-07-31

Applicant: SRI International

Inventor： Kathlynn C. Brown ,  Michael McGuire ,  Shunzi Li ,  Indu Venugopal ,  Curtis Allred

IPC: C12N15/113 ,  A61K31/711 ,  A61K31/7105 ,  A61K47/64

Abstract: Disclosed are compositions comprising a nucleic acid sequence conjugated to one or more MGS peptides. Disclosed are methods of modifying gene expression of a gene of interest comprising administering to a cell a composition comprising a nucleic acid sequence conjugated to one or more MGS peptides, wherein the nucleic acid sequence binds to the RNA transcribed from the gene of interest, the gene of interest or a sequence upstream of the gene of interest. Disclosed are methods of targeting a gene of interest in an intracellular target comprising administering to a cell a composition comprising a nucleic acid sequence conjugated to one or more MGS peptides, wherein the MGS peptide targets the intracellular target, wherein the nucleic acid sequence binds to the RNA transcribed from the gene interest in an intracellular target.

公开(公告)号：US11738089B2

公开(公告)日：2023-08-29

申请号：US16629803

申请日：2018-07-10

Applicant: SRI INTERNATIONAL

Inventor： Kathlynn C. Brown ,  Curtis Allred ,  Michael McGuire

IPC: A61K47/60 ,  A61K47/64 ,  A61P35/00 ,  A61K38/16 ,  A61K45/06

CPC classification number: A61K47/6415 ,  A61K38/168 ,  A61K45/06 ,  A61K47/60 ,  A61P35/00

Abstract: Disclosed herein, are compositions comprising one or more molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer.