公开(公告)号：US11965004B2

公开(公告)日：2024-04-23

申请号：US16629799

申请日：2018-07-10

Applicant: SRI INTERNATIONAL

Inventor： Kathlynn C. Brown ,  Nathan Collins ,  Shunzi “Susan” Li ,  Curtis Allred ,  Keen Chung ,  Michael McGuire

IPC: C07K14/47 ,  A61K47/64 ,  A61P35/00 ,  C07K16/28 ,  A61K38/00

CPC classification number: C07K14/4702 ,  A61K47/64 ,  A61P35/00 ,  C07K16/2803 ,  A61K38/00

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

公开(公告)号：US20240209041A1

公开(公告)日：2024-06-27

申请号：US18390354

申请日：2023-12-20

Applicant: SRI International

Inventor： Kathlynn C. Brown ,  Nathan Collins ,  Shunzi "Susan" Li ,  Curtis Allred ,  Keen Chung ,  Michael McGuire

IPC: C07K14/47 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K14/4702 ,  A61K47/64 ,  A61P35/00 ,  C07K16/2803 ,  A61K38/00

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

公开(公告)号：US20220227823A1

公开(公告)日：2022-07-21

申请号：US16629799

申请日：2018-07-10

Applicant: SRI INTERNATIONAL

Inventor： Kathlynn C. Brown ,  Nathan Collins ,  Shunzi "Susan" Li ,  Curtis Allred ,  Keen Chung ,  Michael McGuire

IPC: C07K14/47 ,  A61K47/64 ,  C07K16/28 ,  A61P35/00

Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.