公开(公告)号：US10882020B1

公开(公告)日：2021-01-05

申请号：US15498145

申请日：2017-04-26

Applicant: SRI International

Inventor： Peter Madrid ,  Pauline Bourbon ,  Michal Avital-Shmilovici ,  Nathan Collins

IPC: C40B50/00 ,  C40B50/18 ,  B01J19/00 ,  C12Q1/6876 ,  C12Q1/68

Abstract: Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. A polymer bead, in accordance with embodiments, has an interior surface and an exterior surface that are topologically segregated from one another. The interior surface includes a protecting group and the exterior surface includes a deprotected group, which can also be referred to as a deprotected functional group. The protecting group can includes a nitrobenzenesulfonamide group that protects an amine group.

公开(公告)号：US20240228495A1

公开(公告)日：2024-07-11

申请号：US17913824

申请日：2021-03-24

Applicant: SRI INTERNATIONAL

Inventor： Thomas R. Webb ,  Chandraiah Lagisetti ,  Diane Beylkin ,  Jaehyeon Park ,  Wei Zhou ,  Peter Madrid ,  Leyi Gong ,  Jeremiah Malerich ,  Chat Gheong Gabriel Fung ,  Raymond Ng ,  Quentin Perron ,  Vinicius Barros Ribeiro da Silva

IPC: C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61K45/06

Abstract: The present disclosure is concerned with 9-hydroxy-6-(pyrrolidin-2-yl)-3, 4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione compounds for the treatment of various viral infections such as, for example, influenza virus. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20210065851A1

公开(公告)日：2021-03-04

申请号：US16965222

申请日：2019-01-30

Applicant: SRI INTERNATIONAL

Inventor： Peter Madrid ,  Nathan Collins ,  Mario Latendresse ,  Jeremiah Malerich ,  Markus Krummenacker

IPC: G16C20/70 ,  G16C10/00 ,  G16C20/10 ,  G16C20/80

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

公开(公告)号：US11961595B2

公开(公告)日：2024-04-16

申请号：US16965222

申请日：2019-01-30

Applicant: SRI INTERNATIONAL

Inventor： Peter Madrid ,  Nathan Collins ,  Mario Latendresse ,  Jeremiah Malerich ,  Markus Krummenacker

IPC: G01N31/00 ,  G16C10/00 ,  G16C20/10 ,  G16C20/70 ,  G16C20/80

CPC classification number: G16C20/70 ,  G16C10/00 ,  G16C20/10 ,  G16C20/80

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

公开(公告)号：US20230393140A1

公开(公告)日：2023-12-07

申请号：US18032020

申请日：2021-10-15

Applicant: SRI International

Inventor： Peter Madrid ,  Nathan Collins ,  Michal Avital-Shmilovici ,  Xiaohe Liu ,  Thomas Shaler

IPC: G01N33/68 ,  G01N33/543 ,  G01N33/551 ,  G01N33/58 ,  G01N21/64

CPC classification number: G01N33/6848 ,  G01N33/54386 ,  G01N2021/6439 ,  G01N33/582 ,  G01N21/6428 ,  G01N33/551

Abstract: An example binding assay includes a plurality of sub-regions, a plurality of synthetic compounds on beads, wherein each of the plurality of sub-regions includes one of the plurality of synthetic compounds, a biological target labeled with a first detectable label in each of the plurality sub-regions, and a biological counter target labeled with a second detectable label in each of the plurality of sub-regions. The biological counter target is configured to bind to the biological target when the biological target is in a first orientation. And, wherein a first subset of the plurality of synthetic compounds bind to the biological target and effect interactions between the biological target and the biological counter target.

公开(公告)号：US20210065848A1

公开(公告)日：2021-03-04

申请号：US16644565

申请日：2017-09-05

Applicant: SRI International

Inventor： Peter Madrid ,  Nathan Collins ,  Michal Avital-Shmilovici ,  Pauline Bourbon ,  Thomas Shaler

IPC: G16C20/20 ,  G16C20/62 ,  G16C20/64

Abstract: Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. An example method includes using logic circuitry to: select a plurality of molecules that include a plurality of subgroups, each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from mass spectrometry characteristics of other molecules of the plurality, and assign the plurality of molecules with a position in a sequence of a plurality of synthetic compounds forming a library. The method further includes defining, as data in a memory circuit of the logic circuitry, the plurality of synthetic compounds that are sequenceable via mass spectrometry using the assigned positions of the plurality of molecules for communicating to other circuitry for formation thereof via coupling chemistry or screening of a particular function.