公开(公告)号：US20250065126A1

公开(公告)日：2025-02-27

申请号：US18810905

申请日：2024-08-21

Applicant: John Cornwell ,  SRI International

Inventor： Christopher Ian Connolly ,  Patrick Denis Lincoln ,  John Cornwell

IPC: A61N1/36

Abstract: Embodiments are directed to systems, devices, and methods for perturbing a biosystem to quantify responsiveness. An example system comprises stimulation circuitry configured to output a plurality of biostimulation signals to a target of a subject, sensor circuitry configured to obtain measures of a biosignal from the subject, and processor circuitry. The processor circuitry is configured to cause the stimulation circuitry to output the plurality of biostimulation signals to perturb a biosystem of the subject, and quantify responsiveness of the biosystem to the perturbation based on the plurality of biostimulation signals and measures of the biosignal responsive to the plurality of biostimulation signals applied to the target.

公开(公告)号：US20170340881A1

公开(公告)日：2017-11-30

申请号：US15608872

申请日：2017-05-30

Applicant: SRI International

Inventor： Christopher Connolly ,  Patrick Lincoln ,  Maneesh Yadav ,  John Cornwell ,  Bhaskar Ramamurthy

IPC: A61N1/36 ,  A61F2/72 ,  A61B5/04

CPC classification number: A61N1/3605 ,  A61B5/04 ,  A61B5/04001 ,  A61B5/4029 ,  A61B5/4836 ,  A61B2503/40 ,  A61F2/72 ,  A61N1/36053 ,  A61N1/3606 ,  G16H40/63 ,  G16H40/67 ,  G16H50/50

Abstract: Systems and methods of generating and applying a synthetic neuromodulatory signal are described. A subject may be put under a particular condition that causes an effect in the subject. While the subject is under the condition, a recording of neurogram signals derived from the condition can be made from the subject. For example, neuronal signals traveling on the vagus nerve of the subject may be monitored and recorded. The neurogram may then be used to create a synthetic neuromodulatory signal that can be administered to a user. When the synthetic neuromodulatory signal is administered to the user, the user may experience the same effect as the subject that had been placed in the condition, even though the user was never put under the same condition.

公开(公告)号：US11752339B2

公开(公告)日：2023-09-12

申请号：US15608872

申请日：2017-05-30

Applicant: SRI International

Inventor： Christopher Connolly ,  Patrick Lincoln ,  Maneesh Yadav ,  John Cornwell ,  Bhaskar Ramamurthy

IPC: A61N1/36 ,  A61F2/72 ,  A61B5/24 ,  A61B5/00 ,  G16H50/50 ,  G16H40/63 ,  G16H40/67 ,  G16H20/10 ,  G16H20/70

CPC classification number: A61N1/3605 ,  A61B5/24 ,  A61B5/4029 ,  A61F2/72 ,  A61N1/3606 ,  A61B5/4836 ,  A61B2503/40 ,  A61N1/36053 ,  G16H20/10 ,  G16H20/70 ,  G16H40/63 ,  G16H40/67 ,  G16H50/50

Abstract: Systems and methods of generating and applying a synthetic neuromodulatory signal are described. A subject may be put under a particular condition that causes an effect in the subject. While the subject is under the condition, a recording of neurogram signals derived from the condition can be made from the subject. For example, neuronal signals traveling on the vagus nerve of the subject may be monitored and recorded. The neurogram may then be used to create a synthetic neuromodulatory signal that can be administered to a user. When the synthetic neuromodulatory signal is administered to the user, the user may experience the same effect as the subject that had been placed in the condition, even though the user was never put under the same condition.