公开(公告)号：US11701016B2

公开(公告)日：2023-07-18

申请号：US16872321

申请日：2020-05-11

Applicant: Stryker European Operations Limited

Inventor： Robert W. Flower ,  Robert Anthony Stead ,  Arthur E. Bailey

IPC: A61B5/02 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/029 ,  A61B5/00 ,  A61B5/024

CPC classification number: A61B5/0261 ,  A61B5/0071 ,  A61B5/029 ,  A61B5/0275 ,  A61B5/02416 ,  A61B5/6826

Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.

公开(公告)号：US11298024B2

公开(公告)日：2022-04-12

申请号：US17234461

申请日：2021-04-19

Applicant: Stryker European Operations Limited

Inventor： John Josef Paul Fengler ,  Robert Anthony Stead

IPC: A61B5/00 ,  H04N9/097 ,  H04N5/238 ,  G02B27/10 ,  H04N5/232 ,  A61B1/04 ,  A61B1/06 ,  A61B1/00 ,  H04N5/33 ,  H04N5/225 ,  H04N5/235 ,  H04N9/04 ,  G01J3/02 ,  A61B1/05 ,  G01J1/00 ,  G01J3/36 ,  G01J1/58 ,  G01J3/44 ,  G02B21/16 ,  G01J3/10 ,  H04N13/204

Abstract: A fluorescence imaging system for imaging an object, the system includes a white light provider that emits white light, an excitation light provider that emits excitation light in a plurality of excitation wavebands for causing the object to emit fluorescent light, a component that directs the white light and excitation light to the object and collects reflected white light and emitted fluorescent light from the object, a filter that blocks light in the excitation wavebands and transmits at least a portion of the reflected white light and fluorescent light, and an image sensor assembly that receives the transmitted reflected white light and the fluorescent light.

公开(公告)号：US11696695B2

公开(公告)日：2023-07-11

申请号：US16588584

申请日：2019-09-30

Applicant: Stryker European Operations Limited

Inventor： Robert W. Flower ,  Robert Anthony Stead ,  Arthur E. Bailey

IPC: A61B5/0275 ,  A61B5/00 ,  A61B5/0295

CPC classification number: A61B5/0275 ,  A61B5/0071 ,  A61B5/0295 ,  A61B5/6826

Abstract: A method and an apparatus for measuring a time-varying change in an amount of blood in a tissue include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain the measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent.

公开(公告)号：US10980420B2

公开(公告)日：2021-04-20

申请号：US15416876

申请日：2017-01-26

Applicant: Stryker European Operations Limited

Inventor： John Josef Paul Fengler ,  Robert Anthony Stead

IPC: A61B5/00 ,  H04N9/097 ,  H04N5/238 ,  G02B27/10 ,  H04N5/232 ,  A61B1/04 ,  A61B1/06 ,  G01J3/02 ,  A61B1/00 ,  A61B1/05 ,  G01J1/00 ,  H04N9/04 ,  G01J3/36 ,  G01J1/58 ,  H04N5/33 ,  H04N5/225 ,  G01J3/44 ,  G02B21/16 ,  G01J3/10 ,  H04N5/235 ,  H04N13/204

Abstract: A fluorescence imaging system for imaging an object, the system includes a white light provider that emits white light, an excitation light provider that emits excitation light in a plurality of excitation wavebands for causing the object to emit fluorescent light, a component that directs the white light and excitation light to the object and collects reflected white light and emitted fluorescent light from the object, a filter that blocks light in the excitation wavebands and transmits at least a portion of the reflected white light and fluorescent light, and an image sensor assembly that receives the transmitted reflected white light and the fluorescent light.