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公开(公告)号：US20150013439A1
公开(公告)日：2015-01-15
申请号：US14372438
申请日：2013-01-25
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
CPC classification number: G01N33/497 , A61B5/083 , A61B5/4845 , A61B10/0045 , G01N1/2202 , G01N1/4022 , G01N21/03 , G01N2001/002 , G01N2001/2282 , G01N2001/4033 , G01N2021/035
Abstract: A micro-analyzer is described. This micro-analyzer includes an outer surface region on a sampler surface that receives liquid droplets, and aggregates and moves the droplets radially toward an inner surface region on the sampler surface that receives the droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient. After the droplets are aggregated, an analysis mechanism in an area within the inner surface region performs analysis on the aggregated droplets.
Abstract translation: 描述微量分析仪。 该微量分析仪包括采样器表面上的接收液滴的外表面区域，并且聚集并将液滴径向移动到接收液滴的采样器表面上的内表面区域。 例如，外表面区域可以包括一组微图案化的同心环，每个环包括一组径向取向的壁 - 槽对。 此外，采样器表面可沿着朝向采样器表面的中心的径向方向越来越少的疏水性，从而产生轴对称的润湿性梯度。 在液滴聚集之后，内表面区域内的分析机构对聚集的液滴进行分析。
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2.发明授权公开(公告)号：US11813050B2
公开(公告)日：2023-11-14
申请号：US16347560
申请日：2017-11-22
Applicant: The Regents of the University of California
Inventor： Cristina E. Davis , Konstantin O. Zamuruyev , Michael Schivo , Nicholas J. Kenyon , Jean-Pierre Delplanque , Alexander A. Aksenov
CPC classification number: A61B5/082 , A61B5/097 , A61M16/0808 , G01N15/0255 , G01N33/497 , A61M15/00 , G01N2015/0288
Abstract: A selective-sorting system for aerosol droplets in human breath includes a mouthpiece to receive a flow of human breath, and a flow path coupled to the mouthpiece. This flow path includes one or more bends that cause the flow of human breath to change direction, which causes aerosol droplets in the flow having different mass-sizes to change direction at different rates. Moreover, the flow path is shaped so that droplets that change direction at different rates are directed to different destinations. The system also includes a collection path, which is coupled to the flow path so that aerosol droplets meeting a specific mass-size criterion are directed into the collection path. A condenser tube is located in the collection path, wherein the condenser tube includes a cooling mechanism that cools the condenser tube to facilitate condensing aerosol droplets to sides of the condenser tube for subsequent collection.
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公开(公告)号：US09398881B2
公开(公告)日：2016-07-26
申请号：US14372438
申请日：2013-01-25
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
CPC classification number: G01N33/497 , A61B5/083 , A61B5/4845 , A61B10/0045 , G01N1/2202 , G01N1/4022 , G01N21/03 , G01N2001/002 , G01N2001/2282 , G01N2001/4033 , G01N2021/035
Abstract: A micro-analyzer is described. This micro-analyzer includes an outer surface region on a sampler surface that receives liquid droplets, and aggregates and moves the droplets radially toward an inner surface region on the sampler surface that receives the droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient. After the droplets are aggregated, an analysis mechanism in an area within the inner surface region performs analysis on the aggregated droplets.
Abstract translation: 描述微量分析仪。 该微量分析仪包括采样器表面上的接收液滴的外表面区域，并且聚集并且将液滴径向移动到接收液滴的采样器表面上的内表面区域。 例如，外表面区域可以包括一组微图案化的同心环，每个环包括一组径向取向的壁 - 槽对。 此外，采样器表面可沿着朝向采样器表面的中心的径向方向越来越少的疏水性，从而产生轴对称的润湿性梯度。 在液滴聚集之后，内表面区域内的分析机构对聚集的液滴进行分析。
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4.发明申请公开(公告)号：US20190274584A1
公开(公告)日：2019-09-12
申请号：US16347560
申请日：2017-11-22
Applicant: The Regents of the University of California
Inventor： Cristina E. Davis , Konstantin O. Zamuruyev , Michael Schivo , Nicholas J. Kenyon , Jean-Pierre Delplanque , Alexander A. Aksenov
IPC: A61B5/08 , A61B5/097 , G01N15/02 , G01N33/497
Abstract: A selective-sorting system for aerosol droplets in human breath includes a mouthpiece to receive a flow of human breath, and a flow path coupled to the mouthpiece. This flow path includes one or more bends that cause the flow of human breath to change direction, which causes aerosol droplets in the flow having different mass-sizes to change direction at different rates. Moreover, the flow path is shaped so that droplets that change direction at different rates are directed to different destinations. The system also includes a collection path, which is coupled to the flow path so that aerosol droplets meeting a specific mass-size criterion are directed into the collection path. A condenser tube is located in the collection path, wherein the condenser tube includes a cooling mechanism that cools the condenser tube to facilitate condensing aerosol droplets to sides of the condenser tube for subsequent collection.
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Patent Agency Ranking
公开(公告)号：US10111606B2
公开(公告)日：2018-10-30
申请号：US14372436
申请日：2013-01-25
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
Abstract: An integrated condenser is described. This integrated condenser includes an outer surface region on a sampler surface that facilitates condensing at least a component in a received gas-phase sample into liquid-phase droplets on the sampler surface, and aggregating and moving the condensed droplets radially toward an inner surface region on the sampler surface that receives the condensed droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient.
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公开(公告)号：US10067119B2
公开(公告)日：2018-09-04
申请号：US15187204
申请日：2016-06-20
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
IPC: G01N1/02 , G01N21/03 , G01N33/497 , G01N1/22 , A61B5/083 , A61B5/00 , A61B10/00 , G01N1/00 , G01N1/40
Abstract: A method for analyzing droplets is described. The droplets can be received on an outer surface region of a sampler surface disposed on a substrate, wherein the sampler surface is increasingly less hydrophobic along a radial direction toward the center of the sampler surface. Next, the droplets can be aggregated and moved toward the center of the sampler surface. The droplets can then be received at an inner surface region of the sampler surface. Next, the droplets can be analyzed using an analysis mechanism in an area in the inner surface region.
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公开(公告)号：US20160290992A1
公开(公告)日：2016-10-06
申请号：US15187204
申请日：2016-06-20
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
IPC: G01N33/497 , A61B5/00 , A61B5/083 , G01N1/40 , G01N1/22
CPC classification number: G01N33/497 , A61B5/083 , A61B5/4845 , A61B10/0045 , G01N1/2202 , G01N1/4022 , G01N21/03 , G01N2001/002 , G01N2001/2282 , G01N2001/4033 , G01N2021/035
Abstract: A method for analyzing droplets is described. The droplets can be received on an outer surface region of a sampler surface disposed on a substrate, wherein the sampler surface is increasingly less hydrophobic along a radial direction toward the center of the sampler surface. Next, the droplets can be aggregated and moved toward the center of the sampler surface. The droplets can then be received at an inner surface region of the sampler surface. Next, the droplets can be analyzed using an analysis mechanism in an area in the inner surface region.
Abstract translation: 描述了分析液滴的方法。 液滴可以被接收在设置在基板上的取样器表面的外表面区域上，其中采样器表面沿径向方向越来越少地朝向取样器表面的中心。 接下来，液滴可以聚集并移动到采样器表面的中心。 然后可以在采样器表面的内表面区域接收液滴。 接下来，可以使用在内表面区域中的区域中的分析机构来分析液滴。
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8.发明申请PERSONAL LUNG FUNCTION MONITORING DEVICE CAPABLE OF EXHALED BREATH ANALYSIS 审中-公开个人肺功能监测装置，可进行呼吸道分析公开(公告)号：US20150164373A1
公开(公告)日：2015-06-18
申请号：US14407225
申请日：2013-06-11
Applicant: The Regents of the University of California
Inventor： Cristina E. Davis , Jean-Pierre Delplanque , Nicholas J. Kenyon , Alice M. Kwan
CPC classification number: A61B5/0803 , A61B5/0002 , A61B5/082 , A61B5/0833 , A61B5/0836 , A61B5/0871 , A61B5/091
Abstract: A personal lung function monitoring device capable of exhaled breath analysis is described. The personal lung function monitoring device includes a physical measuring device and a microcontroller. This physical measuring device further includes a flow chamber configured to receive a flow of exhaled breath from a patient/user, and a set of sensors integrated with the flow chamber. The set of sensors can be used to measure a set of properties of the exhaled breath, which can include one or more common lung function parameters and/or one or more biomarkers of the exhaled breath. The microcontroller is coupled to the physical measuring device and configured to receive analog sensor signals from the set of sensors and transmit the digitized sensor signals to a mobile device. In one embodiment, the personal lung function monitoring device combines peak expiratory flow, spirometry, and exhaled breath biomarker measurements into a single device.
Abstract translation: 描述了能够呼出呼气分析的个人肺功能监测装置。 个人肺功能监测装置包括物理测量装置和微控制器。 该物理测量装置还包括流动室，其构造成从患者/使用者接收呼出气流，以及与流动室结合的一组传感器。 该组传感器可用于测量呼气呼吸的一组特性，其可以包括一个或多个常见肺功能参数和/或呼出呼吸的一个或多个生物标志物。 微控制器耦合到物理测量设备并且被配置为从该组传感器接收模拟传感器信号，并将数字化的传感器信号传送到移动设备。 在一个实施例中，个人肺功能监测装置将呼气峰值流量，肺量计和呼出气生生物标志物测量结合到单个装置中。
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公开(公告)号：US20140358023A1
公开(公告)日：2014-12-04
申请号：US14372436
申请日：2013-01-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
CPC classification number: A61B5/097 , A61B5/082 , A61B10/0051 , G01N1/2202 , G01N33/497 , G01N2001/2282 , G01N2001/4033
Abstract: An integrated condenser is described. This integrated condenser includes an outer surface region on a sampler surface that facilitates condensing at least a component in a received gas-phase sample into liquid-phase droplets on the sampler surface, and aggregating and moving the condensed droplets radially toward an inner surface region on the sampler surface that receives the condensed droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient.
Abstract translation: 描述了一个集成的冷凝器。 该集成冷凝器包括采样器表面上的外表面区域，其有助于将接收的气相样品中的至少一个组分冷凝在采样器表面上的液相液滴中，并且将冷凝的液滴聚集并径向移动到内表面区域上 接收冷凝液滴的采样器表面。 例如，外表面区域可以包括一组微图案化的同心环，每个环包括一组径向取向的壁 - 槽对。 此外，采样器表面可沿着朝向采样器表面的中心的径向方向越来越少的疏水性，从而产生轴对称的润湿性梯度。
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