公开(公告)号：US11008354B2

公开(公告)日：2021-05-18

申请号：US16422831

申请日：2019-05-24

Applicant: The Texas A&M University System

Inventor： John A. Gladysz ,  Kyle G. Lewis ,  Quang H. Luu

IPC: C07F15/06 ,  G01N24/08

Abstract: In an embodiment, a composition including a chiral solvating agent to resolve nuclear magnetic resonance signals of an enantiomer of at least one analyte, where the chiral solvating agent facilitates in the at least one analyte binding to a C2 face or a C3 face of the chiral solvating agent, and where the chiral solvating agent causes an upfield shift or a downfield shift in at least one nuclear magnetic resonance signals corresponding to a 1H, 19F{1H}, or 31P{1H} signal, and where the chiral solvating agent includes a cobalt cation. In another embodiment, a method that includes mixing a chiral solvating agent, including a cobalt cation, with at least one analyte to form a solution, obtaining nuclear magnetic resonance spectra of the solution, and identifying an enantiomer of the at least one analyte. In some embodiments, the method further includes determining enantiomeric purities of the at least one analyte.

公开(公告)号：US09446393B2

公开(公告)日：2016-09-20

申请号：US14417655

申请日：2013-07-29

Applicant: The Texas A&M University System

Inventor： Kyle G. Lewis ,  John A. Gladysz ,  Subrata K. Ghosh

IPC: B01J31/22 ,  C07F15/06 ,  C07F5/02 ,  C07B53/00 ,  C07C211/65 ,  B01J31/02 ,  B01J31/14 ,  B01J31/18

CPC classification number: C07F15/065 ,  B01J31/0255 ,  B01J31/146 ,  B01J31/1805 ,  B01J31/22 ,  B01J31/2295 ,  B01J2231/32 ,  B01J2231/323 ,  B01J2231/341 ,  B01J2531/845 ,  C07B53/00 ,  C07C211/65 ,  C07F5/027

Abstract: In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula Φ-[M(x,y)-L1(w,v)-L2(t,u)-L3]p+An−mZ−p_m. In an embodiment of the present disclosure Φ may be A. In another embodiment Φ may be Δ. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L1, L2, and L3 independently is a ligand comprising a substituted diamine. In some embodiments, An″ comprises a lipophilic anion, where m is from 1 to 3, and where Z− comprises an optional second anion.

Abstract translation: 在一些实施方案中，本公开涉及包含具有式Φ-[M（x，y）-L1（w，v）-L2（t，u）-L3] p + An- mZ-p_m。 在本公开的实施例中，Φ可以是A.在另一个实施例中，Φ可以是Δ。 在本公开的一些实施方案中，M是过渡金属。 在相关实施方案中，p是对应于M的氧化态的整数。在本公开的一些实施方案中，x，y，w，v，t和u中的每一个独立地包含R.在其它实施方案中，x ，y，w，v，t和u独立地包括S.在本公开的实施方案中，L1，L2和L3中的每一个独立地为包含取代的二胺的配体。 在一些实施方案中，An“包含亲脂性阴离子，其中m为1至3，并且其中Z-包含任选的第二阴离子。

公开(公告)号：US20150165429A1

公开(公告)日：2015-06-18

申请号：US14417655

申请日：2013-07-29

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Kyle G. Lewis ,  John A. Gladysz ,  Subrata K. Ghosh

IPC: B01J31/22 ,  C07F5/02 ,  C07F15/06

CPC classification number: C07F15/065 ,  B01J31/0255 ,  B01J31/146 ,  B01J31/1805 ,  B01J31/22 ,  B01J31/2295 ,  B01J2231/32 ,  B01J2231/323 ,  B01J2231/341 ,  B01J2531/845 ,  C07B53/00 ,  C07C211/65 ,  C07F5/027

Abstract: In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula Φ-[M(x,y)-L1(w,v)-L2(t,u)-L3]p+An−mZ−p—m. In an embodiment of the present disclosure Φ may be A. In another embodiment Φ may be Δ. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L1, L2, and L3 independently is a ligand comprising a substituted diamine. In some embodiments, An″ comprises a lipophilic anion, where m is from 1 to 3, and where Z− comprises an optional second anion.

Abstract translation: 在一些实施方案中，本公开涉及包含具有式Φ-[M（x，y）-L1（w，v）-L2（t，u）-L3] p + An- mZ-p-m。 在本公开的实施例中，Φ可以是A.在另一个实施例中，Φ可以是＆Dgr。 在本公开的一些实施方案中，M是过渡金属。 在相关实施方案中，p是对应于M的氧化态的整数。在本公开的一些实施方案中，x，y，w，v，t和u中的每一个独立地包含R.在其它实施方案中，x ，y，w，v，t和u独立地包括S.在本公开的实施方案中，L1，L2和L3中的每一个独立地是包含取代的二胺的配体。 在一些实施方案中，An“包含亲脂性阴离子，其中m为1至3，并且其中Z-包含任选的第二阴离子。