公开(公告)号：US09738731B2

公开(公告)日：2017-08-22

申请号：US14772839

申请日：2014-03-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Ce Tang ,  Naohito Ohno

IPC: A61K31/00 ,  C08B37/00 ,  C12N1/20 ,  C12Q1/02 ,  G01N33/50

CPC classification number: C08B37/0024 ,  C12N1/20 ,  C12Q1/025 ,  G01N33/505 ,  G01N2333/335

Abstract: A growth enhancer for Lactobacillus murinus, Lactobacillus salivarius, or a bacterium that belongs to the genus Lactobacillus and that has a homology of 16S rDNA of 90% or higher with Lactobacillus murinus or Lactobacillus salivarius includes a β-glucan having a molecular weight of from 0.2 K to 50 K. A regulatory T-cell number increasing agent, a method of enhancing growth of a lactic acid bacterium, a method of increasing the number of regulatory T-cells, a method of evaluating a regulatory T-cell number increasing effect, and a method of evaluating a growth enhancing effect on a lactic acid bacterium are also provided.

公开(公告)号：US20250057873A1

公开(公告)日：2025-02-20

申请号：US18719731

申请日：2022-10-12

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Ce Tang

IPC: A61K31/716 ,  A61P35/00 ,  C07K16/28

Abstract: An intestinal tumor suppressor that contains a Dectin-1 inhibitor or a β-glucan having a Dectin-1 inhibitory activity and that suppresses an intestinal tumor through Dectin-1 inhibition; a PGE2 production inhibitor that contains a β-glucan having a Dectin-1 inhibitory activity; and an IL-22BP production promoter containing a β-glucan having a Dectin-1 inhibitory activity, are provided.

公开(公告)号：US20160002364A1

公开(公告)日：2016-01-07

申请号：US14772839

申请日：2014-03-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Ce Tang ,  Naohito Ohno

IPC: C08B37/00 ,  C12Q1/02 ,  G01N33/50 ,  C12N1/20

CPC classification number: C08B37/0024 ,  C12N1/20 ,  C12Q1/025 ,  G01N33/505 ,  G01N2333/335

Abstract: A growth enhancer for Lactobacillus murinus, Lactobacillus salivarius, or a bacterium that belongs to the genus Lactobacillus and that has a homology of 16S rDNA of 90% or higher with Lactobacillus murinus or Lactobacillus salivarius includes a β-glucan having a molecular weight of from 0.2 K to 50 K. A regulatory T-cell number increasing agent, a method of enhancing growth of a lactic acid bacterium, a method of increasing the number of regulatory T-cells, a method of evaluating a regulatory T-cell number increasing effect, and a method of evaluating a growth enhancing effect on a lactic acid bacterium are also provided.

Abstract translation: 具有Lactobacillus murinus或Lactobacillus salivarius的Lactobacillus murinus，唾液乳杆菌或属于乳杆菌属的细菌并且具有90％或更高的同源性的细菌的生长增强剂包括分子量为 0.2K〜50K。调节性T细胞数增加剂，增强乳酸菌生长的方法，增加调节性T细胞数量的方法，评价调节性T细胞数增加效果的方法 ，还提供了对生乳增殖效果进行评价的乳酸菌的评价方法。