公开(公告)号：US20190194376A1

公开(公告)日：2019-06-27

申请号：US16322361

申请日：2017-07-28

Applicant: TOSOH CORPORATION

Inventor： Yukie MAEJIMA ,  Satoru KONDOU ,  Shinya IMATOMI ,  Satoru YAMADA ,  Hiroyuki ITO

IPC: C08F299/02 ,  C12N5/00 ,  C08G81/02 ,  C08G61/02 ,  C08F20/56 ,  C08F20/18

CPC classification number: C08F299/024 ,  C08F20/18 ,  C08F20/56 ,  C08F293/00 ,  C08G61/025 ,  C08G81/02 ,  C08G81/024 ,  C08G2261/126 ,  C08G2261/1424 ,  C08G2261/143 ,  C08G2261/76 ,  C12M3/00 ,  C12N5/0068 ,  C12N2533/30

Abstract: The present invention addresses the problem of providing a block copolymer which is useful as a surface treatment agent for cell culture substrates, said surface treatment agent enabling cell separation in a short period of time. The above-mentioned problem is solved by a block copolymer that includes the following blocks (A), (B) and (C):(A) a temperature-responsive polymer block that has a lower critical solution temperature (LCST) within the range of from 0° C. to 50° C. with respect to water (B) a hydrophilic polymer block that does not have an LCST within the range of from 0° C. to 50° C., while having an HLB value within the range of from 9 (inclusive) to 20 (exclusive) (C) a hydrophobic polymer block that does not have an LCST within the range of from 0° C. to 50° C., while having an HLB value within the range of from 0 (inclusive) to 9 (exclusive).