公开(公告)号：US20190194376A1

公开(公告)日：2019-06-27

申请号：US16322361

申请日：2017-07-28

Applicant: TOSOH CORPORATION

Inventor： Yukie MAEJIMA ,  Satoru KONDOU ,  Shinya IMATOMI ,  Satoru YAMADA ,  Hiroyuki ITO

IPC: C08F299/02 ,  C12N5/00 ,  C08G81/02 ,  C08G61/02 ,  C08F20/56 ,  C08F20/18

CPC classification number: C08F299/024 ,  C08F20/18 ,  C08F20/56 ,  C08F293/00 ,  C08G61/025 ,  C08G81/02 ,  C08G81/024 ,  C08G2261/126 ,  C08G2261/1424 ,  C08G2261/143 ,  C08G2261/76 ,  C12M3/00 ,  C12N5/0068 ,  C12N2533/30

Abstract: The present invention addresses the problem of providing a block copolymer which is useful as a surface treatment agent for cell culture substrates, said surface treatment agent enabling cell separation in a short period of time. The above-mentioned problem is solved by a block copolymer that includes the following blocks (A), (B) and (C):(A) a temperature-responsive polymer block that has a lower critical solution temperature (LCST) within the range of from 0° C. to 50° C. with respect to water (B) a hydrophilic polymer block that does not have an LCST within the range of from 0° C. to 50° C., while having an HLB value within the range of from 9 (inclusive) to 20 (exclusive) (C) a hydrophobic polymer block that does not have an LCST within the range of from 0° C. to 50° C., while having an HLB value within the range of from 0 (inclusive) to 9 (exclusive).

公开(公告)号：US20250059310A1

公开(公告)日：2025-02-20

申请号：US18721350

申请日：2022-12-21

Applicant: TOSOH CORPORATION ,  KAI PHOTONICS CO., LTD.

Inventor： Satoru YAMADA ,  Misaki WATANABE ,  Fumiaki KATAGIRI ,  Takahiro KITAGAWA ,  Ryuichi SAKASHITA ,  Yasuhiro KOIKE

IPC: C08F234/00

Abstract: It is an object to provide a method for efficiently producing an N-alkylmaleimide-based polymer that has an excellent optical characteristic, excellent heat resistance, and excellent mechanical strength. A method for producing an N-alkylmaleimide-based polymer in accordance with an aspect of the present invention includes using an oil-soluble radical polymerization initiator to carry out suspension polymerization, in an aqueous medium in the presence of at least one dispersant selected from the group consisting of a nonionic compound having no hydrogen bonded to oxygen or nitrogen, a polyacrylate salt, and a polyalkylene glycol, with respect to a monomer mixture consisting of 20% by weight to 100% by weight of N-alkylmaleimide and 0% by weight to 80% by weight of other copolymerizable monomers, the N-alkylmaleimide being represented by the following general formula (1): where R represents a C1-C12 linear alkyl group, a C3-C12 branched alkyl group, or a C3-C6 cyclic alkyl group.