公开(公告)号：US20030202179A1

公开(公告)日：2003-10-30

申请号：US10135854

申请日：2002-04-29

Applicant: The Curators of the University of Missouri

Inventor： David W. Larsen ,  Zhi Xu ,  Wayne Garver

IPC: G01J003/42

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42

Abstract: The invention concerns improvements in spectrophotometry. Aspects of the invention may be used independently or together to increase the sensitivity of spectrophotometry. One aspect of the invention is a spectrophotometer detection circuit. In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing and optical system components to promote equilibrium. Another preferred embodiment has a unitary solid metal housing with a hollowed portion defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments. Many noise sources would not normally be considered in conventional spectrophotometry because the magnitude of particular noise sources dominates device performance.

Abstract translation: 本发明涉及分光光度法的改进。 本发明的各方面可以独立地或一起使用来提高分光光度法的灵敏度。 本发明的一个方面是分光光度计检测电路。 在本发明的这个方面，在当前模式下，归因于参考和采样光束的电流被消除。 检测电路产生与电流差成比例的第一电压和与参考或采样光束之一成比例的第二电压。 两种电压均可用于同时测量和分析。 本发明的另一方面涉及热稳定性。 根据本发明，在壳体和光学系统部件之间建立导热性以促进平衡。 另一个优选实施例具有整体的实心金属外壳，其具有限定为安装和放置光学系统部件的中空部分。 识别和识别分光光度计中的重要噪声源形成本发明的一个方面，其有利于优选实施例中的特征和特征的组合。 常规分光光度法通常不会考虑许多噪声源，因为特定噪声源的大小主导器件性能。