公开(公告)号：US20190250159A1

公开(公告)日：2019-08-15

申请号：US16396972

申请日：2019-04-29

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud Almasri ,  Shibajyoti Ghosh Dastider ,  Shuping Zhang ,  Majed El Dweik ,  Nuh Sadi Yuksek ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G01N33/569 ,  B01L3/00 ,  B03C5/00 ,  B03C5/02 ,  G01N33/543

CPC classification number: G01N33/56916 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N27/06 ,  G01N33/5438 ,  G01N2333/245 ,  G01N2333/255

Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

公开(公告)号：US11422134B2

公开(公告)日：2022-08-23

申请号：US16396972

申请日：2019-04-29

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud Almasri ,  Shibajyoti Ghosh Dastider ,  Shuping Zhang ,  Majed El Dweik ,  Nuh Sadi Yuksek ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G01N33/569 ,  B03C5/00 ,  G01N33/543 ,  B01L3/00 ,  B03C5/02 ,  G01N27/02 ,  G01N27/06

Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

公开(公告)号：US10274492B2

公开(公告)日：2019-04-30

申请号：US15094045

申请日：2016-04-08

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud Almasri ,  Shibajyoti Ghosh Dastider ,  Shuping Zhang ,  Majed El Dweik ,  Nuh Sadi Yuksek ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G01N33/569 ,  B03C5/00 ,  G01N33/543 ,  B01L3/00 ,  B03C5/02 ,  G01N27/06

Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

公开(公告)号：US10989867B2

公开(公告)日：2021-04-27

申请号：US16849908

申请日：2020-04-15

Applicant: The Curators of the University of Missouri

Inventor： Edward C. Kinzel ,  Mahmoud Almasri ,  Chuang Qu ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G02B6/036 ,  G02B6/02 ,  G03F7/00

Abstract: A fiber-based sensor and a method of forming a fiber-based sensor using microsphere lithography techniques in which a microsphere array is applied to a surface of a tip of an optical fiber to provide for microsphere lithography fabrication of a desired pattern on the tip of the optical fiber. The characteristics of the pattern define sensing capabilities of the sensor to provide for chemical and/or biological sensing.

公开(公告)号：US20160299138A1

公开(公告)日：2016-10-13

申请号：US15094045

申请日：2016-04-08

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud Almasri ,  Shibajyoti Ghosh Dastider ,  Shuping Zhang ,  Majed El Dweik ,  Nuh Sadi Yuksek ,  Ibrahem Jasim

IPC: G01N33/569 ,  G01N27/27 ,  B01L3/00 ,  B03C5/02 ,  G01N33/543 ,  G01N27/447 ,  B03C5/00

CPC classification number: G01N33/56916 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N27/06 ,  G01N33/5438 ,  G01N2333/245 ,  G01N2333/255

Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

Abstract translation: 本文公开了一种变换传感器装置的示例性实施例，其能够通过检测电极阵列所呈现的阻抗变化来检测和定量样品中特定细菌的存在。 在示例性实施例中，通过将聚焦电极阵列包括在下降通道中来将感兴趣物质的浓度聚焦到检测区域来提高灵敏度。 聚焦电极包括处于倾斜方向的相对电极对。 聚焦电极还可以包括从斜坡电极延伸的倾斜的薄膜指状电极。 在另一示例性实施例中，定位俘获电极以将感兴趣物质的浓度捕获到检测电极阵列上。