公开(公告)号：US11422134B2

公开(公告)日：2022-08-23

申请号：US16396972

申请日：2019-04-29

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud Almasri ,  Shibajyoti Ghosh Dastider ,  Shuping Zhang ,  Majed El Dweik ,  Nuh Sadi Yuksek ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G01N33/569 ,  B03C5/00 ,  G01N33/543 ,  B01L3/00 ,  B03C5/02 ,  G01N27/02 ,  G01N27/06

Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

公开(公告)号：US10274492B2

公开(公告)日：2019-04-30

申请号：US15094045

申请日：2016-04-08

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud Almasri ,  Shibajyoti Ghosh Dastider ,  Shuping Zhang ,  Majed El Dweik ,  Nuh Sadi Yuksek ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G01N33/569 ,  B03C5/00 ,  G01N33/543 ,  B01L3/00 ,  B03C5/02 ,  G01N27/06

Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

公开(公告)号：US20190250159A1

公开(公告)日：2019-08-15

申请号：US16396972

申请日：2019-04-29

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud Almasri ,  Shibajyoti Ghosh Dastider ,  Shuping Zhang ,  Majed El Dweik ,  Nuh Sadi Yuksek ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G01N33/569 ,  B01L3/00 ,  B03C5/00 ,  B03C5/02 ,  G01N33/543

CPC classification number: G01N33/56916 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N27/06 ,  G01N33/5438 ,  G01N2333/245 ,  G01N2333/255

Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

公开(公告)号：US20230258568A1

公开(公告)日：2023-08-17

申请号：US18170815

申请日：2023-02-17

Applicant: The Curators of the University of Missouri

Inventor： Mahmoud ALMASRI ,  Jiayu Liu ,  Sura Muhsin

IPC: G01N21/65 ,  G01N21/552 ,  G01N33/543

CPC classification number: G01N21/658 ,  G01N21/554 ,  G01N33/5438

Abstract: A plasmonic sensor achieving high sensitivities by using a metallized nanoantennae array patterned on the longitudinal side of a fiber optic cable is disclosed herein. The sensor is capable of single and multiplex detection of biomarkers, viruses, food and waterborne pathogens, proteins, and other chemical and biological specimens. Plasmonic sensor embodiments including SERS and RI sensing arrays are disclosed.

公开(公告)号：US10989867B2

公开(公告)日：2021-04-27

申请号：US16849908

申请日：2020-04-15

Applicant: The Curators of the University of Missouri

Inventor： Edward C. Kinzel ,  Mahmoud Almasri ,  Chuang Qu ,  Ibrahem Jasim ,  Jiayu Liu

IPC: G02B6/036 ,  G02B6/02 ,  G03F7/00

Abstract: A fiber-based sensor and a method of forming a fiber-based sensor using microsphere lithography techniques in which a microsphere array is applied to a surface of a tip of an optical fiber to provide for microsphere lithography fabrication of a desired pattern on the tip of the optical fiber. The characteristics of the pattern define sensing capabilities of the sensor to provide for chemical and/or biological sensing.