公开(公告)号：US20240361337A1

公开(公告)日：2024-10-31

申请号：US18660434

申请日：2024-05-10

Applicant: The Curators of the University of Missouri

Inventor： James L. Cook ,  Aaron M. Stoker ,  Chantelle C. Bozynski ,  Keiichi Kuroki ,  Cristi R. Cook ,  Emily Leary

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2800/60

Abstract: Methods for predicting canine hip dysplasia (CHD) in an immature canine subject are provided. The methods include the use of concentration profiles of a plurality of polypeptides, including C2C, CTX-I, CTX-II, RANKL, PIICP, COMP, PINP. Also provided are CHD biomarker profiles for predicting or diagnosing CHD in immature or young canines before CHD develops. Diagnostic reagents and kits for the same are also provided.

公开(公告)号：US20240164368A1

公开(公告)日：2024-05-23

申请号：US18520265

申请日：2023-11-27

Applicant: The Curators of the University of Missouri ,  The Trustees of Columbia University in the City of New York

Inventor： James L. Cook ,  Clark T. Hung ,  Eric Lima ,  Aaron Stoker

IPC: A01N1/02

CPC classification number: A01N1/0226 ,  A01N1/021 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0284

Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.

公开(公告)号：US20190059911A1

公开(公告)日：2019-02-28

申请号：US16107671

申请日：2018-08-21

Applicant: The Curators of the University of Missouri

Inventor： Ferris M. Pfeiffer ,  Aaron M. Stoker ,  James L. Cook

IPC: A61B17/16 ,  A61B17/34

Abstract: Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may be adapted to contract from a first diameter to a second diameter that is less than the first diameter. The contraction of the cutting surface from the first diameter to the second diameter may define a tapered profile between the first diameter and the second diameter suitable for obtaining a tapered graft.

公开(公告)号：US20220175604A1

公开(公告)日：2022-06-09

申请号：US17560731

申请日：2021-12-23

Applicant: The Curators of the University of Missouri

Inventor： James L. Cook ,  Cory Crecelius ,  Trent Guess ,  Kylee Rucinski ,  Jonathan Williams

IPC: A61H1/02 ,  A61H1/00

Abstract: The present invention is an apparatus and method for use in a treatment for prevention of arthrofibrosis that includes a first and a second substantially L-shaped frames, each L-shaped frame having a first member and a second member extending from the first member in a substantially perpendicular direction and terminating in a first end, a fixed plate extending between the first members of the L-shaped frames, the fixed plate being parallel with the first members of the L-shaped frames, a movable plate pivotally coupled to the first ends of the first members of the L-shaped frames with, a pneumatic piston coupled to the movable plate and the fixed plate, a hand operated valve operatively coupled to the pneumatic piston and a goniometer coupled to the movable plate and one of the L-shaped frames, the goniometer adapted and configured to indicate the angle between the movable plate and the fixed plate.

公开(公告)号：US20210239711A1

公开(公告)日：2021-08-05

申请号：US17168871

申请日：2021-02-05

Applicant: The Curators of the University of Missouri

Inventor： James L. Cook ,  Aaron M. Stoker ,  Chantelle C. Bozynski ,  Keiichi Kuroki ,  Cristi R. Cook ,  Emily Leary

IPC: G01N33/68

Abstract: Methods for predicting canine hip dysplasia (CHD) in an immature canine subject are provided. The methods include the use of concentration profiles of a plurality of polypeptides, including C2C, CTX-I, CTX-II, RANKL, PIICP, COMP, PINP. Also provided are CHD biomarker profiles for predicting or diagnosing CHD in immature or young canines before CHD develops. Diagnostic reagents and kits for the same are also provided.

公开(公告)号：US20170281198A1

公开(公告)日：2017-10-05

申请号：US15582287

申请日：2017-04-28

Applicant: The Curators of the University of Missouri

Inventor： Ferris M. Pfeiffer ,  Aaron M. Stoker ,  James L. Cook

IPC: A61B17/16

CPC classification number: A61B17/1635 ,  A61B17/16 ,  A61B17/1604 ,  A61B17/1613 ,  A61B17/1615 ,  A61B17/1622 ,  A61B17/3417 ,  A61B17/3439 ,  B23B51/04 ,  B23B51/0406 ,  B23B51/0413 ,  B23B51/0453 ,  B23B51/05 ,  B23B2251/428 ,  B23B2251/54

Abstract: Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may be adapted to contract from a first diameter to a second diameter that is less than the first diameter. The contraction of the cutting surface from the first diameter to the second diameter may define a tapered profile between the first diameter and the second diameter suitable for obtaining a tapered graft.

公开(公告)号：US09733257B2

公开(公告)日：2017-08-15

申请号：US15290613

申请日：2016-10-11

Applicant: The Curators of the University of Missouri

Inventor： James L. Cook ,  Cristi R. Cook ,  Aaron M. Stoker ,  Keiichi Kuroki ,  Bridget Colleen Garner ,  Richard Evans ,  Brandon Lee Roller ,  Prakash Sidha Jayabalan

IPC: G01N33/68 ,  C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/6887 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/5308 ,  G01N2333/52 ,  G01N2333/5421 ,  G01N2800/105 ,  G01N2800/56

Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.

公开(公告)号：US12005018B2

公开(公告)日：2024-06-11

申请号：US17560731

申请日：2021-12-23

Applicant: The Curators of the University of Missouri

Inventor： James L. Cook ,  Cory Crecelius ,  Trent Guess ,  Kylee Rucinski ,  Jonathan Williams

IPC: A61H1/02 ,  A61H1/00

CPC classification number: A61H1/024 ,  A61H1/00 ,  A61H2201/0134 ,  A61H2201/0149 ,  A61H2201/0192 ,  A61H2201/1207 ,  A61H2201/123 ,  A61H2201/1238 ,  A61H2201/1246 ,  A61H2201/1253 ,  A61H2201/1623 ,  A61H2201/1628 ,  A61H2201/164 ,  A61H2201/1642 ,  A61H2201/1676 ,  A61H2201/5023 ,  A61H2201/5056 ,  A61H2201/5069 ,  A61H2203/0431 ,  A61H2203/0456 ,  A61H2205/102

Abstract: The present invention is an apparatus and method for use in a treatment for prevention of arthrofibrosis that includes a first and a second substantially L-shaped frames, each L-shaped frame having a first member and a second member extending from the first member in a substantially perpendicular direction and terminating in a first end, a fixed plate extending between the first members of the L-shaped frames, the fixed plate being parallel with the first members of the L-shaped frames, a movable plate pivotally coupled to the first ends of the first members of the L-shaped frames with, a pneumatic piston coupled to the movable plate and the fixed plate, a hand operated valve operatively coupled to the pneumatic piston and a goniometer coupled to the movable plate and one of the L-shaped frames, the goniometer adapted and configured to indicate the angle between the movable plate and the fixed plate.

公开(公告)号：US20170030925A1

公开(公告)日：2017-02-02

申请号：US15290613

申请日：2016-10-11

Applicant: The Curators of the University of Missouri

Inventor： James L. Cook ,  Cristi R. Cook ,  Aaron M. Stoker ,  Keiichi Kuroki ,  Bridget Colleen Garner ,  Richard Evans ,  Brandon Lee Roller ,  Prakash Sidha Jayabalan

IPC: G01N33/68

CPC classification number: G01N33/6887 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/5308 ,  G01N2333/52 ,  G01N2333/5421 ,  G01N2800/105 ,  G01N2800/56

Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.

Abstract translation: 公开了用于诊断骨关节炎（OA）和确定治疗的生物标志物，生物标志物组和方法，使用来自受试者的测试样品中某些多肽的表达水平的测量，包括MCP1，IL8，KC，MMP2，MMP3，载脂蛋白A1和 载脂蛋白E.还描述了用于监测OA治疗功效，诊断试剂和试剂盒的相关方法。

公开(公告)号：US11864554B2

公开(公告)日：2024-01-09

申请号：US17967598

申请日：2022-10-17

Applicant: The Curators of the University of Missouri ,  The Trustees of Columbia University in the City of New York

Inventor： James L. Cook ,  Clark T. Hung ,  Eric Lima ,  Aaron Stoker

IPC: A01N1/02

CPC classification number: A01N1/0226 ,  A01N1/021 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0284

Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.