公开(公告)号：US20170204200A1

公开(公告)日：2017-07-20

申请号：US15321055

申请日：2015-06-25

Applicant: UCB BIOPHARMA SPRL

Inventor： Pallavi BHATTA ,  Emma DAVE ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS

IPC: C07K16/46

Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

公开(公告)号：US20180127498A1

公开(公告)日：2018-05-10

申请号：US15573185

申请日：2016-05-09

Applicant: UCB Biopharma SPRL

Inventor： Pallavi BHATTA ,  Emma DAVE ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS ,  Bryan John SMITH

IPC: C07K16/28 ,  C07K16/18 ,  A61P21/04 ,  A61P17/00 ,  A61P25/00 ,  A61P37/00 ,  A61P7/00

CPC classification number: C07K16/283 ,  A61K2039/505 ,  A61P7/00 ,  A61P17/00 ,  A61P21/04 ,  A61P25/00 ,  A61P37/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/74

Abstract: The disclosure relates to antibody fusion proteins specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.