公开(公告)号：US20180134774A1

公开(公告)日：2018-05-17

申请号：US15795874

申请日：2017-10-27

Applicant: UCB Biopharma SPRL

Inventor： Ralph ADAMS ,  Pallavi BHATTA ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS

IPC: C07K16/18 ,  C07K16/28

CPC classification number: C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

公开(公告)号：US20170204200A1

公开(公告)日：2017-07-20

申请号：US15321055

申请日：2015-06-25

Applicant: UCB BIOPHARMA SPRL

Inventor： Pallavi BHATTA ,  Emma DAVE ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS

IPC: C07K16/46

Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

公开(公告)号：US20180127498A1

公开(公告)日：2018-05-10

申请号：US15573185

申请日：2016-05-09

Applicant: UCB Biopharma SPRL

Inventor： Pallavi BHATTA ,  Emma DAVE ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS ,  Bryan John SMITH

IPC: C07K16/28 ,  C07K16/18 ,  A61P21/04 ,  A61P17/00 ,  A61P25/00 ,  A61P37/00 ,  A61P7/00

CPC classification number: C07K16/283 ,  A61K2039/505 ,  A61P7/00 ,  A61P17/00 ,  A61P21/04 ,  A61P25/00 ,  A61P37/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/74

Abstract: The disclosure relates to antibody fusion proteins specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

公开(公告)号：US20180346603A1

公开(公告)日：2018-12-06

申请号：US15779417

申请日：2016-12-01

Applicant: UCB BIOPHARMA SPRL

Inventor： Pallavi BHATTA ,  Laura STARKIE ,  Michael John WRIGHT

IPC: C07K16/46 ,  C07K16/14 ,  C07K14/395 ,  C12N15/10

CPC classification number: C07K16/00 ,  C07K14/395 ,  C07K16/14 ,  C07K16/468 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23

Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A-X:Y-B) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets.