公开(公告)号：US20210140892A1

公开(公告)日：2021-05-13

申请号：US17149490

申请日：2021-01-14

Applicant: United Kingdom Research and Innovation

Inventor： Pavel Matousek ,  Nicholas Stone ,  Benjamin Gardner

IPC: G01N21/65 ,  G01N33/483

Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.

公开(公告)号：US11346785B2

公开(公告)日：2022-05-31

申请号：US17149490

申请日：2021-01-14

Applicant: United Kingdom Research and Innovation

Inventor： Pavel Matousek ,  Nicholas Stone ,  Benjamin Gardner

IPC: G01J3/44 ,  G01N21/65 ,  G01N33/483

Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.

公开(公告)号：US10935440B2

公开(公告)日：2021-03-02

申请号：US15740217

申请日：2016-06-29

Applicant: United Kingdom Research and Innovation

Inventor： Pavel Matousek ,  Nicholas Stone ,  Benjamin Gardner

IPC: A61B5/01 ,  G01K11/12 ,  G01K13/00 ,  G01K13/02

Abstract: The disclosure relates to a clinical thermometer for non-invasive measurement of sub-cutaneous temperature of tissue of a human or animal subject. Probe light is collected from a collection region spatially offset from an entry region on a visible surface of the subject, following scattering within the tissue, and a temperature of the tissue is determined from Raman spectral features in the collected light.

公开(公告)号：US20190277766A1

公开(公告)日：2019-09-12

申请号：US16345061

申请日：2017-10-27

Applicant: UNITED KINGDOM RESEARCH AND INNOVATION

Inventor： Pavel Matousek ,  Nicholas Stone ,  Benjamin Gardner

IPC: G01N21/65 ,  G01N33/483

Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.

公开(公告)号：US20210102849A1

公开(公告)日：2021-04-08

申请号：US17124199

申请日：2020-12-16

Applicant: United Kingdom Research and Innovation

Inventor： Pavel Matousek ,  Nicholas Stone ,  Benjamin Gardner

IPC: G01K11/12 ,  G01K13/00 ,  G01K13/02

Abstract: The disclosure relates to a clinical thermometer for non-invasive measurement of sub-cutaneous temperature of tissue of a human or animal subject. Probe light is collected from a collection region spatially offset from an entry region on a visible surface of the subject, following scattering within the tissue, and a temperature of the tissue is determined from Raman spectral features in the collected light.

公开(公告)号：US10942123B2

公开(公告)日：2021-03-09

申请号：US16345061

申请日：2017-10-27

Applicant: UNITED KINGDOM RESEARCH AND INNOVATION

Inventor： Pavel Matousek ,  Nicholas Stone ,  Benjamin Gardner

IPC: G01J3/44 ,  G01N21/65 ,  G01N33/483

Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.