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公开(公告)号：US20210389180A1
公开(公告)日：2021-12-16
申请号：US17282438
申请日：2019-10-04
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Kay Sowoidnich , Michael Towrie
Abstract: There are disclosed methods and apparatus (10) for measuring Raman spectral features (52) of a sample (12), from which background light of variable intensity is also received, for example due to the incidence of ambient light (14) or due to variable fluorescence. Detection pixels (42) and storage pixels (44) are defined on a CCD device (40). Laser probe light (22) is directed to the sample. In a repeated cycle of first and second intervals, in each first interval background light is received at detection pixels, and in each second interval both background light and scattered laser probe light is received at the detection pixels. The accumulated signal from each of the first and second intervals is retained in the storage pixels during the second and first intervals respectively. In other aspects laser probe light is directed to the sample during both of the first and second intervals, but has a different wavelength in each interval.
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公开(公告)号：US10935440B2
公开(公告)日：2021-03-02
申请号：US15740217
申请日：2016-06-29
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Nicholas Stone , Benjamin Gardner
Abstract: The disclosure relates to a clinical thermometer for non-invasive measurement of sub-cutaneous temperature of tissue of a human or animal subject. Probe light is collected from a collection region spatially offset from an entry region on a visible surface of the subject, following scattering within the tissue, and a temperature of the tissue is determined from Raman spectral features in the collected light.
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公开(公告)号：US20190277766A1
公开(公告)日：2019-09-12
申请号：US16345061
申请日：2017-10-27
Applicant: UNITED KINGDOM RESEARCH AND INNOVATION
Inventor： Pavel Matousek , Nicholas Stone , Benjamin Gardner
IPC: G01N21/65 , G01N33/483
Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.
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公开(公告)号：US20210102849A1
公开(公告)日：2021-04-08
申请号：US17124199
申请日：2020-12-16
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Nicholas Stone , Benjamin Gardner
Abstract: The disclosure relates to a clinical thermometer for non-invasive measurement of sub-cutaneous temperature of tissue of a human or animal subject. Probe light is collected from a collection region spatially offset from an entry region on a visible surface of the subject, following scattering within the tissue, and a temperature of the tissue is determined from Raman spectral features in the collected light.
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公开(公告)号：US10942123B2
公开(公告)日：2021-03-09
申请号：US16345061
申请日：2017-10-27
Applicant: UNITED KINGDOM RESEARCH AND INNOVATION
Inventor： Pavel Matousek , Nicholas Stone , Benjamin Gardner
IPC: G01J3/44 , G01N21/65 , G01N33/483
Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.
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Patent Agency Ranking
公开(公告)号：US20210140892A1
公开(公告)日：2021-05-13
申请号：US17149490
申请日：2021-01-14
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Nicholas Stone , Benjamin Gardner
IPC: G01N21/65 , G01N33/483
Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.
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公开(公告)号：US20250130173A1
公开(公告)日：2025-04-24
申请号：US18836105
申请日：2023-02-07
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Sara Mosca , Nicholas Stone
IPC: G01N21/65 , G01N33/483
Abstract: Methods and apparatus for detecting one or more properties of a sub-surface volume of a diffusely scattering sample are disclosed, where the diffusely scattering sample comprises surface enhanced Raman Spectroscopy (SERS) probes, the SERS probes being spectrally responsive to a stimulus. The stimulus is provided in a varying form at the sub-surface volume, and during the varying stimulus, probe light is directed to an entry region on a surface of the sample. A portion of the probe light is collected, including elements of said probe light Raman scattered from said SERS probes, at a collection region on the surface of the sample, the collection region being spaced from the entry region. The collected Raman scattered elements are then measured, and variations in the measured Raman scattered elements which are induced by the variations in the stimulus are detected. One or more properties may then be detected based on the detected variations in the measured Raman scattered elements. For example, the variations in the stimulus may comprise changes in the stimulus over time at the sub-surface volume, and the variations in the measured Raman scattered elements which are induced by the variations in the stimulus may then comprise changes in the measured Raman scattered elements over time.
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公开(公告)号：US20230139070A1
公开(公告)日：2023-05-04
申请号：US17912328
申请日：2021-02-17
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Nicholas Stone , Adrian Ghita
IPC: A61B5/00
Abstract: There are disclosed methods and apparatus for measuring water content in tissue in-vivo, for example in sub-surface or sub-cutaneous tissue of a human or animal subject. The measurement may be made through diffusely scattering overlying tissue such as skin tissue, by: directing probe light to an entry region on a surface of the overlying tissue; collecting said probe light from a collection region on the surface of the overlying tissue, the collection region being spatially offset from the entry region, the collected probe light comprising probe light inelastically scattered into the Raman OH stretching bands by water present in the sub-surface tissue; detecting, in the collected probe light, one or more first spectral features of the probe light inelastically scattered into the Raman OH stretching bands; and measuring water content in the sub-surface tissue using the one or more first spectral features.
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公开(公告)号：US11346785B2
公开(公告)日：2022-05-31
申请号：US17149490
申请日：2021-01-14
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Nicholas Stone , Benjamin Gardner
IPC: G01J3/44 , G01N21/65 , G01N33/483
Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.
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公开(公告)号：US11300451B2
公开(公告)日：2022-04-12
申请号：US17282438
申请日：2019-10-04
Applicant: United Kingdom Research and Innovation
Inventor： Pavel Matousek , Kay Sowoidnich , Michael Towrie
Abstract: There are disclosed methods and apparatus (10) for measuring Raman spectral features (52) of a sample (12), from which background light of variable intensity is also received, for example due to the incidence of ambient light (14) or due to variable fluorescence. Detection pixels (42) and storage pixels (44) are defined on a CCD device (40). Laser probe light (22) is directed to the sample. In a repeated cycle of first and second intervals, in each first interval background light is received at detection pixels, and in each second interval both background light and scattered laser probe light is received at the detection pixels. The accumulated signal from each of the first and second intervals is retained in the storage pixels during the second and first intervals respectively. In other aspects laser probe light is directed to the sample during both of the first and second intervals, but has a different wavelength in each interval.
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