公开(公告)号：US20210198633A1

公开(公告)日：2021-07-01

申请号：US17057130

申请日：2019-05-30

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Maria Cristina NOSTRO ,  Farida SARANGI ,  Roman KORYTNIKOV ,  Emily MCGAUGH ,  Frankie Hoi Chun POON

IPC: C12N5/071

Abstract: Methods and compositions are provided for producing PDX1+/NKX6-1+ pancreatic progenitor cells from a PDX1+ endodermal cell population. The method comprises contacting the endodermal cell population with an EGF component and tankyrase inhibitor that binds to an adenosine subsite of a tankyrase enzyme, to induce the differentiation of at least a portion of the PDX1+ endodermal cell population into PDX1+NKX6-1+ pancreatic progenitor cells.