公开(公告)号：US20250009783A1

公开(公告)日：2025-01-09

申请号：US18702339

申请日：2021-11-16

Applicant: UNIVERSITY OF MACAU

Inventor： Chunming WANG ,  Jiaxi CHEN ,  Daping XIE ,  Zhe ZHANG

IPC: A61K31/728 ,  C08B37/08

Abstract: The present invention relates to the cross-technical fields of medicine, material chemistry, glycobiology and the like, in particular to a sulfonated hyaluronic acid compound, a preparation method therefor and an application thereof. The structural formula of the sulfonated hyaluronic acid compound is shown as in formula (I), wherein R is alkali metal cation or hydrogen; R1, R2, R3 and R4 are respectively independently selected from hydrogen or sulfonate ions and R1, R2, R3 and R4 cannot be hydrogen at the same time, 10

公开(公告)号：US20250025493A1

公开(公告)日：2025-01-23

申请号：US18708217

申请日：2022-02-28

Applicant: UNIVERSITY OF MACAU

Inventor： Chunming WANG ,  Xiaoyu YIN ,  Lintao WANG ,  Zhe ZHANG

IPC: A61K31/736 ,  A61P17/14 ,  C08B37/00 ,  C12P19/04 ,  C12P19/14

Abstract: The present disclosure relates to the technical field of skin hair regeneration, and in particular to glucohexaose and a preparation method therefor and an application thereof, and a hair regeneration preparation. The molecular structure of the glucohexaose is Man-Man-Man-Man-Glc-Glc. The gulcohexaose can specifically stimulate local macrophages to release a cytokine network mainly comprising CCL5 chemotactic factors, recruit lymphocytes mainly comprising regulatory T cells, induce an immune cascade reaction, regulate an immune microenvironment, activate rapid proliferation and differentiation of hair follicle stem cells at a hair follicle carina and at the lower end of the carina, remarkably promote periodic regeneration of hair follicles, and accelerate the process of driving the hair follicles to enter a growth period from a resting period, so as to achieve the effect of treating alopecia.