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公开(公告)号：US20250009783A1
公开(公告)日：2025-01-09
申请号：US18702339
申请日：2021-11-16
Applicant: UNIVERSITY OF MACAU
Inventor： Chunming WANG , Jiaxi CHEN , Daping XIE , Zhe ZHANG
IPC: A61K31/728 , C08B37/08
Abstract: The present invention relates to the cross-technical fields of medicine, material chemistry, glycobiology and the like, in particular to a sulfonated hyaluronic acid compound, a preparation method therefor and an application thereof. The structural formula of the sulfonated hyaluronic acid compound is shown as in formula (I), wherein R is alkali metal cation or hydrogen; R1, R2, R3 and R4 are respectively independently selected from hydrogen or sulfonate ions and R1, R2, R3 and R4 cannot be hydrogen at the same time, 10
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公开(公告)号：US11201503B2
公开(公告)日：2021-12-14
申请号：US16711465
申请日：2019-12-12
Applicant: University of Macau
Inventor： Zhicong Huang , Chi-Seng Lam , Pui-In Mak , Rui Paulo Da Silva Martins
Abstract: An exemplary embodiment of the present invention is a wireless power transmission circuit that provides power to a load of variable resistance with an alternating current (AC) power source induced at a secondary coil in a secondary side of the circuit by a primary coil in a primary side of the said circuit. The wireless power transmission circuit includes a switch-controlled capacitor (SCC) and a semi-active rectifier (SAR). The SCC connects to the AC power source. The SCC includes a first capacitor connected in parallel with two electrically controllable switches in series. The SAR connects to output of the SCC for rectifying the output of the SCC, wherein the SAR comprises a bridge circuit that includes two electrically controllable switches. A control angle of the SCC and a conduction angle of the SAR are regulated to provide a load impedance that matches the impedance of the coils.
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公开(公告)号：US20210184499A1
公开(公告)日：2021-06-17
申请号：US16711465
申请日：2019-12-12
Applicant: University of Macau
Inventor： Zhicong HUANG , Chi-Seng LAM , Pui-In MAK , Rui Paulo da Silva MARTINS
Abstract: An exemplary embodiment of the present invention is a wireless power transmission circuit that that provides power to a load of variable resistance with an alternating current (AC) power source induced at a secondary coil in a secondary side of the circuit by a primary coil in a primary side of the said circuit. The wireless power transmission circuit includes a switch-controlled capacitor (SCC) and a semi-active rectifier (SAR). The SCC connects to the AC power source. The SCC includes a first capacitor connected in parallel with two electrically controllable switches in series. The SAR connects to output of the SCC for rectifying the output of the SCC, wherein the SAR comprises a bridge circuit that includes two electrically controllable switches. Both switches in the SCC are turned on for half a cycle and complement to each other and are turned off with a time delay relative to the zero cross points of the AC power source, and the time delay is a control angle of the SCC. Both switches in the SAR are turned on for half a cycle and complement to each other and are turned off with a time delay relative to the zero cross points of the AC power source, and that time delay is a conduction angle of the SAR. The control angle of the SCC and the conduction angle of the SAR are regulated to provide a load impedance that matches the impedance of the coils, so that the wireless power transmission provides constant power output and enhance the power transmission efficiency.
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4.发明授权公开(公告)号：US11007266B2
公开(公告)日：2021-05-18
申请号：US16032482
申请日：2018-07-11
Applicant: UNIVERSITY OF MACAU
Inventor： Hang Fai Kwok
Abstract: Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence suggests the mechanisms by which angiotensin II (AngII) elevates blood pressure and enhances cardiovascular remodeling and damage may be distinct. In vascular smooth muscle cells, a metaloproteinase ADAM17 mediates epidermal growth factor receptor (EGER) transactivation, which may be responsible for cardiovascular remodeling but not hypertension induced by AngII. Treatment with a human cross-reactive ADAM17 inhibitory antibody (A9B8) also prevented cardiovascular, remodeling and ER stress but not hypertension in C57Bl/6 mice infused with AngII. In vitro data further supported these findings. In conclusion, vascular ADAM17 mediates AngII-induced cardiovascular remodeling via EGFR activation independent of blood pressure regulation. ADAM17 presents a unique therapeutic target for antibodies such as A9B8 for the prevention of hypertensive complications.
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5.发明授权公开(公告)号：US11000225B2
公开(公告)日：2021-05-11
申请号：US16024217
申请日：2018-06-29
Inventor： Tim Lei , Achim Klug , Sio Hang Pun , Changhao Chen , Mang I. Vai , Peng Un Mak , Elizabeth McCullagh
Abstract: Various embodiments of the present technology generally relate to a single monolithic IC to perform simultaneous optogenetic neural inhibition and extracellular electrophysiological recording in-vivo. Some embodiments include a low input capacitance (e.g., 9.7 pF) amplifier particularly tailored for the use of high-impedance electrodes to conduct single neuron extracellular recording integrated with programmable high current drivers for optogenetic stimulation or inhibition on the same IC chip. Some embodiments use a noise model to guide the IC design process to obtain parameters for optimal signal-to-noise ratio. The performance of the IC chip was demonstrated on an anesthetized gerbil expressed with inhibitory optogenetic protein (Halorhodopsin). Spontaneous action potentials from the fifth nerve of the brainstem were recorded by the amplifier and were subsequently inhibited by laser illumination. As a result, various embodiments of the IC allow neuroscience research and neural engineering applications to be conducted in an entirely new direction and can potentially be used in treatments for human mental diseases in the future.
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Patent Agency Ranking
公开(公告)号：US10436726B2
公开(公告)日：2019-10-08
申请号：US14881889
申请日：2015-10-13
Applicant: UNIVERSITY OF MACAU
Inventor： Ka-Meng Lei , Pui-In Mak , Man-Kay Law , Rui Paulo Da Silva Martins
Abstract: A palm-size portable μNMR relaxometer system for performing multi-step multi-sample chemical/biological assays, comprising a PCB having a CMOS μNMR transceiver and a DMF device integrated thereon. A portable magnet has an inner gap configured to at least partially receive the DMF device. The DMF device comprises a platform of electrodes including a sensing site and receives one or more samples for analysis at an electrode and automatically transports the one or more samples on individual paths sequentially to the sensing site, for performing sensing on each sample sequentially. A Butterfly coil disposed on the PCB and underneath the DMF device and is at least partially received in the inner gap. The Butterfly coil excites the sample at the μNMR sensing site by transducing a magnetic field produced at the sensing site to an electrical signal which is processed by the CMOS μNMR transceiver to produce an analytical signal.
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公开(公告)号：US20190292567A1
公开(公告)日：2019-09-26
申请号：US16364458
申请日：2019-03-26
Applicant: UNIVERSITY OF MACAU
Inventor： Qingsong XU
Abstract: A novel piezo-driven cell injection system with force feedback overcomes the unsatisfied force interaction between the pipette needle and embryos in conventional position control. By integrating semiconductor strain-gage sensors for detecting the cell penetration force and the micropipette relative position in real time, the developed cell microinjection system features high operation speed, confident success rate, and high survival rate. The effectiveness of the developed cell injection system is experimentally verified by penetrating zebrafish embryos. The injection of 100 embryos are conducted with separate position control and force control. Results indicate that the force control enables a survival rate of 86%, which is higher than the survival rate of 82% produced by the position control in the same control environment. The experimental results quantitatively demonstrate the superiority of force control over conventional position control for the first time.
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8.发明申请公开(公告)号：US20190034819A1
公开(公告)日：2019-01-31
申请号：US16019306
申请日：2018-06-26
Applicant: UNIVERSITY OF MACAU
Inventor： Hou IAN , Yan ZHANG , Kam Weng TAM
IPC: G06N99/00 , H03K19/195 , B82Y10/00 , H01L39/22
Abstract: Multi-mode resonator is usually used to design broadband bandpass filters and the cross-shape resonator (CSR) is one of its typical types. The possibility of utilizing cross-shape multi-mode resonators is explored as a signal controller for superconducting qubits that are coplanar to the resonator. The multi-mode qubit-resonator coupling facilitates the design of future quantum information processor.
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公开(公告)号：US10011555B2
公开(公告)日：2018-07-03
申请号：US15727638
申请日：2017-10-09
Applicant: University of Macau
Inventor： Ming Yuen Lee , Zaijun Zhang , Guohui Li
IPC: C07C59/52 , A61K31/352 , A61K31/192 , C07C51/47 , C07C59/90 , C07C59/54 , C07C51/347
CPC classification number: C07C59/52 , A61K31/192 , A61K31/352 , A61K2300/00 , C07C51/347 , C07C51/47 , C07C59/54 , C07C59/90
Abstract: This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.
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公开(公告)号：US10003195B1
公开(公告)日：2018-06-19
申请号：US15425270
申请日：2017-02-06
Applicant: University of Macau
Inventor： Man-Chung Wong , Chi-Seng Lam , Lei Wang
CPC classification number: H02J3/1842 , H02J3/1864 , Y02E40/12 , Y02E40/16 , Y02E40/22 , Y02E40/40
Abstract: A hybrid-STATCOM for providing compensating reactive power required by a load, the hybrid-STATCOM comprising: a TCLC part for each electric power phase, each TCLC part comprising: a coupling inductor; a power filter capacitor; and a thyristor-controlled reactor connected in series with a power filter inductor; and an active inverter part comprising: a voltage source inverter for each electric power phase; and a DC-link capacitor connected in parallel with the voltage source inverters. The control strategy of the hybrid-STATCOM is separated into two parts: TCLC part control and Active inverter part control. The TCLC part control is based on the instantaneous pq theory and aims to compensate the loading reactive power with the controllable TCLC part impedance. The active inverter part control is based on the instantaneous active and reactive current id-iq method and aims to improve the overall performance of the hybrid-STATCOM under different voltage and current conditions.
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