公开(公告)号：US10376535B2

公开(公告)日：2019-08-13

申请号：US15561466

申请日：2016-03-28

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Richard G. Moore ,  Rakesh K. Singh ,  Naohiro Yano

IPC: A61K48/00 ,  C07H21/02 ,  A61K31/7105 ,  A61K45/06 ,  A61K31/5025 ,  A61K31/58 ,  A61K31/713 ,  A61P35/00 ,  A61K33/24 ,  A61K45/00 ,  G01N33/574

Abstract: Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.