公开(公告)号：US11034719B2

公开(公告)日：2021-06-15

申请号：US16884179

申请日：2020-05-27

Applicant: University of Rochester

Inventor： Rakesh K. Singh ,  Richard G. Moore

IPC: C07J71/00 ,  A61K31/401 ,  A61K31/415 ,  A61K31/565 ,  A61K31/575 ,  A61K31/58 ,  A61K45/06

Abstract: The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

公开(公告)号：US20230000823A1

公开(公告)日：2023-01-05

申请号：US17835545

申请日：2022-06-08

Applicant: University of Rochester

Inventor： Deepak Sahasrabudhe ,  Rakesh K. Singh

IPC: A61K31/404 ,  A61P35/02

Abstract: The present disclosure relates to compounds and methods for treating cancer, the methods comprising administering to the subject a compound of formula (1). In some embodiments, the disclosure provides compounds and methods for inhibiting IQGAP1.

公开(公告)号：US10376535B2

公开(公告)日：2019-08-13

申请号：US15561466

申请日：2016-03-28

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Richard G. Moore ,  Rakesh K. Singh ,  Naohiro Yano

IPC: A61K48/00 ,  C07H21/02 ,  A61K31/7105 ,  A61K45/06 ,  A61K31/5025 ,  A61K31/58 ,  A61K31/713 ,  A61P35/00 ,  A61K33/24 ,  A61K45/00 ,  G01N33/574

Abstract: Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.

公开(公告)号：US12076310B2

公开(公告)日：2024-09-03

申请号：US17835545

申请日：2022-06-08

Applicant: University of Rochester

Inventor： Deepak Sahasrabudhe ,  Rakesh K. Singh

IPC: A61K31/404 ,  A61P35/02

CPC classification number: A61K31/404 ,  A61P35/02

Abstract: The present disclosure relates to compounds and methods for treating cancer, the methods comprising administering to the subject a compound of formula (1). In some embodiments, the disclosure provides compounds and methods for inhibiting IQGAP1.

公开(公告)号：US10683324B2

公开(公告)日：2020-06-16

申请号：US15990235

申请日：2018-05-25

Applicant: University of Rochester

Inventor： Rakesh K. Singh ,  Richard G. Moore

IPC: A61K31/401 ,  C07J71/00 ,  A61K31/415 ,  A61K31/565 ,  A61K31/575 ,  A61K31/58 ,  A61K45/06

Abstract: The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.